0974-4150 (Online)
0974-4169 (Print)

Author(s): Tamizharuvi T, Indira R, Jaisankar V


DOI: Not Available

Address: Tamizharuvi T, Indira R and Jaisankar V*
PG and Research Department of Chemistry, Presidency College, Chennai – 600 005.
*Corresponding Author

Published In:   Volume - 5,      Issue - 5,     Year - 2012

Biodegradable synthetic polyesters have recently found widespread application in biomedical and engineering fields, such as tissue engineering, therapeutic delivery and bioimaging. Currently, many applications involving lactic acid based polyesters are being explored with polymers derived from monomers that are endogenous to the human metabolism. In terms of mechanical stability, crystallinity, hydrophobicity and biocompatibility, polyesters synthesised from these monomers can display a wide range of applications. In this investigation, a series of novel biodegradable copolyesters synthesised from lactic acid, terephthalic acid and ethylene glycol/ 1,4 butane diol through a two step process of melt polycondensation using titanium tetra isopropoxide as catalyst. The synthesised random copolyesters were characterised by means of solubility, viscosity measurements, IR, 1H NMR, 13C NMR spectral analysis and hydrolytic degradation tests. The copolyesters remained unchanged in simulated gastric fluid (pH -1.2) and gradually degraded in simulated intestinal fluid (pH – 7.4). They were later tried as enteric coating materials on diclofenac sodium core tablets and their drug release patterns correspond to BP standard drug release profile of enteric coating material.

Cite this article:
Tamizharuvi T, Indira R, Jaisankar V. Synthesis, characterisation and drug release pattern of certain lactic acid based random copolyesters. Asian J. Research Chem. 5(5): May 2012; Page 611-615.

Recomonded Articles:

Author(s): Jeevan Dontulwar, Manjiri Nagmote, Rajesh Singru

DOI: 10.5958/0974-4150.2017.00139.0         Access: Open Access Read More

Author(s): NivedhaSrinivasan, VinothKumar.S

DOI: 10.5958/0974-4150.2018.00154.2         Access: Open Access Read More

Author(s): J. Margaret Marie, S. Santhi, R. Puvanakrishnan, R. Nanthini

DOI:         Access: Open Access Read More

Author(s): Ravi Prakash Mahor, Versha Parcha, Yogendra Singh, Rajiv Sharma, Anil Bhandari

DOI:         Access: Open Access Read More

Author(s): Indira R., Harihara Priya G., Tamizharuvi T., Jaisankar V.

DOI:         Access: Open Access Read More

Author(s): Sachin R. Kumbhoje, Zaki Husain J. Tamboli, Dr. John I. D’Souza

DOI:         Access: Open Access Read More

Author(s): Tamizharuvi T, Indira R, Jaisankar V

DOI:         Access: Open Access Read More

Author(s): T. Sivaramakrishnan, G. Annamalai, G. Elango

DOI: 10.5958/0974-4150.2020.00021.8         Access: Closed Access Read More

Asian Journal of Research in Chemistry (AJRC) is an international, peer-reviewed journal devoted to pure and applied chemistry..... Read more >>>

RNI: Not Available                     
DOI: 10.5958/0974-4150 

Popular Articles

Recent Articles