ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): Ravi Prakash Mahor, Versha Parcha, Yogendra Singh, Rajiv Sharma, Anil Bhandari

Email(s): raviprakashmahor@gmail.com

DOI: Not Available

Address: Ravi Prakash Mahor1*, Versha Parcha2, Yogendra Singh1, Rajiv Sharma3 and Anil Bhandari1
1Faculty of Pharmaceutical Sciences, Jodhpur National University, Jodhpur, Rajasthan, India.
2Department of Pharmaceutical Sciences, SBS PG Institute of Biomedical Sciences and Research, Balawala, Dehradun – 248 161, Uttarakhand.
3Site Quality Head, Alembic Ltd., Baddi, Himachal Pradesh, India
*Corresponding Author

Published In:   Volume - 4,      Issue - 11,     Year - 2011


ABSTRACT:
A simple, precise and accurate HPLC method has been validated to measure lamivudine and zidovudine at single wavelength (270 nm) in order to assess in vitro drug release profile of drug from tablet formulation. The chromatographic separation was achieved on a Hypersil SS C18 (250 mm × 4.6 mm, 5µm) analytical column. Methanol was used as the mobile phase, at a flow rate of 1 ml/min. The release of lamivudine and zidovudine from in dissolution medium (distilled water) and in the reference dissolution medium (0.1 N HCl) was studied using the USP type II apparatus. The parameters similarity factor, according to current FDA guidelines, dissolution efficiency, t50 and dissolution rate constant (k) were employed to compare dissolution profiles. It was concluded that test dissolution method was equivalent to the reference dissolution method.


Cite this article:
Ravi Prakash Mahor, Versha Parcha, Yogendra Singh, Rajiv Sharma, Anil Bhandari. Validation of a Quantitative Method for Simultaneous Estimation and Comparison of Dissolution Method for Combination Tablet of Lamivudine and Zidovudine. Asian J. Research Chem. 4(11): Nov., 2011; Page 1793-1799.


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DOI: 10.5958/0974-4150 

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