A simple precise, rapid accurate and sensitive non-aqueous potentiometric titration method was developed for quantitative determination of lafutadine from pharmaceutical dosage form. The titration was carried out using standardized 0.1 N perchloric acid. The proposed method was found to be precise with % RSD <1 (n = 6). The method showed strict linearity (r2 > 0.99) between 20 % to 100 % of 100 mg of drug substance weight. The percentage recovery of lafutadine in the optimized method was between 99.878 to 101.315 %. The method is also found to be rugged when checked by different analysts and using different lots of reagents and different makes of titrators.
Cite this article:
Rele Rajan V., Gurav Pankaj J., Sawant Swapnil A.. A Validated Non-aqueous Potentiometric Titration Method for the Quantitative Determination of Lafutadine from Pharmaceutical Preparation. Asian J. Research Chem. 5(6): June, 2012; Page 722-724.