ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): Lakshmi Sivasubramanian, T. Tintu, K.S. Lakshmi

Email(s): lakshmiss@hotmail.com

DOI: Not Available

Address: Lakshmi Sivasubramanian1*, T. Tintu2 and K.S. Lakshmi2
1Department of Pharmaceutical Analysis, Bharat Institute of Technology (Pharmacy), Mangalpally (V), Ibrahimpatnam (M), RR district, Hyderabad – 501 510, Andhra Pradesh
2Department of Pharmaceutical Analysis, SRM College of Pharmacy, SRM University, Kattankulathur – 603 203, Tamil Nadu.
*Corresponding Author

Published In:   Volume - 5,      Issue - 8,     Year - 2012


ABSTRACT:
The present work reports a method for the simultaneous determination of Paracetamol and Lornoxicam in binary mixture. The method was based on HPTLC separation of the two drugs followed by densitometric measurements of their spots at 254nm. The separation was carried out using Ethyl acetate: Methanol: Chloroform: Triethylamine in the ratio of 9:0.5:0.5:0.2 v/v/v/v as mobile phase on Merck HPTLC aluminium sheets of silica gel 60 GF254. The linearity was in the range of 0.5-2.5 µg/spot for both the drugs. Proposed method has been successfully applied to pharmaceutical formulation. No chromatographic interference from the tablet excipients was found. The method was validated in terms of precision, robustness, recovery and limits of detection and quantitation.


Cite this article:
Lakshmi Sivasubramanian, T. Tintu, K.S. Lakshmi. HPTLC for the Simultaneous Determination of Paracetamol and Lornoxicam in Pharmaceutical Dosage Form. Asian J. Research Chem. 5(8): August, 2012; Page 1025-1028.


Recomonded Articles:

Author(s): Y. Padmavathi, Akari Anjali, Nayaka Raghavendra Babu, P Ravi Kumar

DOI: 10.5958/0974-4150.2017.00064.5         Access: Open Access Read More

Author(s): Vatchavai Bhaskara Raju, Bonthu Mohan Gandhi, Kamatham Srinivas Sumanth, Kolli Srinivas, Tupakula N Venkata Lakshmi Neeraja

DOI: 10.5958/0974-4150.2017.00030.X         Access: Open Access Read More

Author(s): Alka Verma, Bhupesh Verma, Sunil Kumar Prajapati, Kishu Tripathi

DOI:         Access: Open Access Read More

Author(s): SS Chitlange, Kiran Bagri, DM Sakarkar

DOI:         Access: Open Access Read More

Author(s): Banerjee S, Bonde CG, Merukar SS, Patil YR

DOI:         Access: Open Access Read More

Author(s): B. Balaswami, P. Venkata Ramana, B. Subba Rao, P. Sanjeeva

DOI: 10.5958/0974-4150.2018.00023.8         Access: Open Access Read More

Author(s): Ismail, R Rajavel, M Ganesh, M Jagadeeswaran, K Srinivasan, J Valarmathi, T Sivakumar

DOI:         Access: Open Access Read More

Author(s): PA Jadhav, CS Raut, JP Bidada, BB Buwa, PN Dhabale, SC Dhawale

DOI:         Access: Open Access Read More

Author(s): Tentu Nageswara Rao, Muralidhar Reddy Avuthu, B. Venkata Reddy, SNVS Murthy

DOI: 10.5958/0974-4150.2016.00076.6         Access: Open Access Read More

Author(s): Manorama B. Motegaonkar, S. D. Salunke

DOI: 10.5958/0974-4150.2017.00025.6         Access: Open Access Read More

Author(s): R.K. Nanda, S.E. Potawale, V.V. Bhagwat, S.C.Hamane, R. S. Deshmukh

DOI:         Access: Open Access Read More

Asian Journal of Research in Chemistry (AJRC) is an international, peer-reviewed journal devoted to pure and applied chemistry..... Read more >>>

RNI: Not Available                     
DOI: 10.5958/0974-4150 

Popular Articles


Recent Articles




Tags