ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): Sudesh D. Shambharkar, Purnima D. Hamrapurkar

Email(s): sudeshshambharkar@gmail.com

DOI: Not Available

Address: Sudesh D. Shambharkar*, Purnima D. Hamrapurkar
Department of Pharmaceutical Analysis, Prin K.M. Kundnani College of Pharmacy, Jote Joy Building, Rambhau Salgaokar Marg, Cuffe Parade, Colaba, Mumbai-400 005, India
*Corresponding Author

Published In:   Volume - 6,      Issue - 10,     Year - 2013


ABSTRACT:
A simple, selective and precise gradient HPLC method has been developed for simultaneous estimation of Mefenamic acid and Paracetamol combination from pharmaceutical dosage form. The separation was accomplished on an HiQSil reversed phase C18 column, 250 mm ×4.6mm I.D., 5µm column using two mobile phases i.e. A as methanol: 50mM potassium dihydrogen orthophosphate (pH = 7.5)(20:80 v/v) and B as methanol in a gradient elution mode. The flow rate was 1mL/min. The eluents were monitored with a UV detector set at 245 nm as detection wavelength. The investigated validation elements showed the method has acceptable specificity, accuracy, linearity, precision, robustness and high sensitivity. Detection and quantification limits were established at 0.02 µg/ml and 0.05 µg/ml respectively. A stability indicating HPLC method has been established for analysis of Mefenamic acid and Paracetamol combination. The drug was subjected to stress conditions of hydrolysis, oxidation, photolysis, and thermal decomposition.


Cite this article:
Sudesh D. Shambharkar, Purnima D. Hamrapurkar. Optimization and Establishment of Validated stability indicating RP-HPLC Method for Simultaneous Estimation of Mefenamic acid and Paracetamol from Tablet Dosage Form. Asian J. Research Chem. 6(10): October 2013; Page 926-931.


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