ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): Vaishali V. Karkhanis, Anandkumari D. Captain

Email(s): vesli@rediffmail.com

DOI: Not Available

Address: Vaishali V. Karkhanis*, Dr. (Mrs). Anandkumari D. Captain
A.R. College of Pharmacy and G.H. Patel Institute of Pharmacy V.V. Nagar- 388120 Gujarat
*Corresponding Author

Published In:   Volume - 6,      Issue - 12,     Year - 2013


ABSTRACT:
An accurate, sensitive and precise RP-HPLC method has been developed and validated for the estimation of Vildagliptin (VIL) from bulk drug and Pharmaceutical Dosage form. The separation was achieved by Hypersil C18 column (250mm X 4.6mm, 5µm) in isocratic mode, with mobile phase comprises of Acetonitrile : Buffer in proportion of 25:75v/v, buffer was 0.02M Potassium Di-hydrogen Phosphate (pH 4.5 adjusted with Ortho Phosphoric Acid). The flow rate of mobile phase was 1.0ml/min and employing UV detection with 215nm wavelengths. The retention time of VIL was 4.353 min.The calibration curve was found to be linear within the concentration range of 10µg/ml to 30µg/ml. The regression data for calibration curve shows good linear relationship with r2 = 0.9997. The method was validated in accordance with the requirements of ICH guidelines. Moreover, the proposed analytical method was applied to monitor the formulation commercially available.


Cite this article:
Vaishali V. Karkhanis, Anandkumari D. Captain. Development and Validation of a Liquid Chromatographic Method for Estimation of Vildagliptin in Tablet Dosage Form. Asian J. Research Chem. 6(12): December 2013; Page 1166-1168.


Recomonded Articles:

Author(s): Bulusu Lakshmi Sushma1, Gutta Madhusudhan, Anireddy Jayashree

DOI: 10.5958/0974-4150.2017.00014.1         Access: Open Access Read More

Author(s): Vatchavai Bhaskara Raju, Bonthu Mohan Gandhi, Kamatham Srinivas Sumanth, Kolli Srinivas, Tupakula N Venkata Lakshmi Neeraja

DOI: 10.5958/0974-4150.2017.00030.X         Access: Open Access Read More

Author(s): Y. Padmavathi, Akari Anjali, Nayaka Raghavendra Babu, P Ravi Kumar

DOI: 10.5958/0974-4150.2017.00064.5         Access: Open Access Read More

Author(s): Alka Verma, Bhupesh Verma, Sunil Kumar Prajapati, Kishu Tripathi

DOI:         Access: Open Access Read More

Author(s): SS Chitlange, Kiran Bagri, DM Sakarkar

DOI:         Access: Open Access Read More

Author(s): Banerjee S, Bonde CG, Merukar SS, Patil YR

DOI:         Access: Open Access Read More

Author(s): B. Balaswami, P. Venkata Ramana, B. Subba Rao, P. Sanjeeva

DOI: 10.5958/0974-4150.2018.00023.8         Access: Open Access Read More

Author(s): Ismail, R Rajavel, M Ganesh, M Jagadeeswaran, K Srinivasan, J Valarmathi, T Sivakumar

DOI:         Access: Open Access Read More

Author(s): Manorama B. Motegaonkar, S. D. Salunke

DOI: 10.5958/0974-4150.2017.00025.6         Access: Open Access Read More

Author(s): JR Rao, Mohan Kumar, SS Yadav

DOI:         Access: Open Access Read More

Author(s): PA Jadhav, CS Raut, JP Bidada, BB Buwa, PN Dhabale, SC Dhawale

DOI:         Access: Open Access Read More

Author(s): Mukund Nagarnaik, Arun Sarjoshi, Ajay Bodkhe, Bhupendra Khanal, Mayuri Pise, Girish Pandya

DOI: 10.5958/0974-4150.2015.00102.9         Access: Open Access Read More

Asian Journal of Research in Chemistry (AJRC) is an international, peer-reviewed journal devoted to pure and applied chemistry..... Read more >>>

RNI: Not Available                     
DOI: 10.5958/0974-4150 

Popular Articles


Recent Articles




Tags