ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): Rajyalakshmi Ch., Rambabu C.

Email(s): anants2020@gmail.com

DOI: Not Available

Address: Rajyalakshmi Ch.1*, Rambabu C.2
1Department of Chemistry, Vishnu Institute of Technology, Bhimavaram, A.P, India
2Department of Chemistry, Acharya Nagarjuna University, Guntur, A.P, India
*Corresponding Author

Published In:   Volume - 6,      Issue - 12,     Year - 2013


ABSTRACT:
Two Simple, fast and reliable derivative spectrophotometric methods were developed for determination of Sildenafil in bulk and pharmaceutical dosage forms. The solutions of standard and the sample were prepared in methanol. The quantitative determination of the drug was carried out using the zero order derivative values measured at 292 nm and the first order derivative values measured at 274 nm. Calibration graphs constructed at their wavelengths of determination were linear in the concentration range of Sildenafil using 30-50 µg.mL-1 for both the methods. All the proposed methods have been extensively validated as per ICH guidelines. There was no significant difference between the performance of the proposed methods regarding the mean values and standard deviations. These methods were successfully applied to pharmaceutical formulations because no interferences from tablet excipients were found. The proposed methods were found to be simple, sensitive, accurate, precise, rapid and economical for the routine quality control application of Sildenafil in pharmaceutical formulations.


Cite this article:
Rajyalakshmi Ch., Rambabu C.. Derivative Spectrophotometric Methods for Determination of Sildenafil in Pharmaceutical Formulation. Asian J. Research Chem. 6(12): December 2013; Page 1116-1120.


Recomonded Articles:

Author(s): Bulusu Lakshmi Sushma1, Gutta Madhusudhan, Anireddy Jayashree

DOI: 10.5958/0974-4150.2017.00014.1         Access: Open Access Read More

Author(s): Y. Padmavathi, Akari Anjali, Nayaka Raghavendra Babu, P Ravi Kumar

DOI: 10.5958/0974-4150.2017.00064.5         Access: Open Access Read More

Author(s): Vatchavai Bhaskara Raju, Bonthu Mohan Gandhi, Kamatham Srinivas Sumanth, Kolli Srinivas, Tupakula N Venkata Lakshmi Neeraja

DOI: 10.5958/0974-4150.2017.00030.X         Access: Open Access Read More

Author(s): Alka Verma, Bhupesh Verma, Sunil Kumar Prajapati, Kishu Tripathi

DOI:         Access: Open Access Read More

Author(s): Banerjee S, Bonde CG, Merukar SS, Patil YR

DOI:         Access: Open Access Read More

Author(s): Mukund Nagarnaik, Arun Sarjoshi, Ajay Bodkhe, Bhupendra Khanal, Mayuri Pise, Girish Pandya

DOI: 10.5958/0974-4150.2015.00102.9         Access: Open Access Read More

Author(s): B. Balaswami, P. Venkata Ramana, B. Subba Rao, P. Sanjeeva

DOI: 10.5958/0974-4150.2018.00023.8         Access: Open Access Read More

Author(s): Ismail, R Rajavel, M Ganesh, M Jagadeeswaran, K Srinivasan, J Valarmathi, T Sivakumar

DOI:         Access: Open Access Read More

Author(s): Tentu Nageswara Rao, Muralidhar Reddy Avuthu, B. Venkata Reddy, SNVS Murthy

DOI: 10.5958/0974-4150.2016.00076.6         Access: Open Access Read More

Author(s): PA Jadhav, CS Raut, JP Bidada, BB Buwa, PN Dhabale, SC Dhawale

DOI:         Access: Open Access Read More

Author(s): Prasanna Reddy Battu, MS Reddy

DOI:         Access: Open Access Read More

Asian Journal of Research in Chemistry (AJRC) is an international, peer-reviewed journal devoted to pure and applied chemistry..... Read more >>>

RNI: Not Available                     
DOI: 10.5958/0974-4150 

Popular Articles


Recent Articles




Tags