Author(s):
Rajyalakshmi Ch., Rambabu C.
Email(s):
anants2020@gmail.com
DOI:
Not Available
Address:
Rajyalakshmi Ch.1*, Rambabu C.2
1Department of Chemistry, Vishnu Institute of Technology, Bhimavaram, A.P, India
2Department of Chemistry, Acharya Nagarjuna University, Guntur, A.P, India
*Corresponding Author
Published In:
Volume - 6,
Issue - 12,
Year - 2013
ABSTRACT:
Two Simple, fast and reliable derivative spectrophotometric methods were developed for determination of Sildenafil in bulk and pharmaceutical dosage forms. The solutions of standard and the sample were prepared in methanol. The quantitative determination of the drug was carried out using the zero order derivative values measured at 292 nm and the first order derivative values measured at 274 nm. Calibration graphs constructed at their wavelengths of determination were linear in the concentration range of Sildenafil using 30-50 µg.mL-1 for both the methods. All the proposed methods have been extensively validated as per ICH guidelines. There was no significant difference between the performance of the proposed methods regarding the mean values and standard deviations. These methods were successfully applied to pharmaceutical formulations because no interferences from tablet excipients were found. The proposed methods were found to be simple, sensitive, accurate, precise, rapid and economical for the routine quality control application of Sildenafil in pharmaceutical formulations.
Cite this article:
Rajyalakshmi Ch., Rambabu C.. Derivative Spectrophotometric Methods for Determination of Sildenafil in Pharmaceutical Formulation. Asian J. Research Chem. 6(12): December 2013; Page 1116-1120.
Cite(Electronic):
Rajyalakshmi Ch., Rambabu C.. Derivative Spectrophotometric Methods for Determination of Sildenafil in Pharmaceutical Formulation. Asian J. Research Chem. 6(12): December 2013; Page 1116-1120. Available on: https://ajrconline.org/AbstractView.aspx?PID=2013-6-12-8