ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): Freddy H. Havaldar, Azadkumar S. Sharma

Email(s): azadsharma83@gmail.com

DOI: Not Available

Address: Freddy H. Havaldar* and Azadkumar S. Sharma
Nadkarny-Sacasa Research Laboratory, Department of Chemistry, St. Xavier’s College, Mumbai - 400 001.
*Corresponding Author

Published In:   Volume - 6,      Issue - 2,     Year - 2013


ABSTRACT:
A new Mannich base of quinazolin-4-one derivatives possessing 1,3,4-oxadiazole ring have been synthesized by reacting 3-[4-(5-thioxo-4,5-dihydro-[1,3,4]oxadiazole-2-yl)-phenyl]-2-phenyl-3H-quinazolin-4-one (4) with different secondary amines and formaldehyde using N,N-dimethylformamide as the solvent to afford 3-[4-(4-substituted amino-4-ylmethyl-5-thioxo-4,5-dihydro-[1,3,4]oxadiazole-2-yl)-phenyl]-2-phenyl-3H-quinazolin-4-ones (5a-e). The structures of the newly synthesized compounds have been established by analytical and spectral methods. The compounds have also been screened for their biological activity.


Cite this article:
Freddy H. Havaldar, Azadkumar S. Sharma. Syntheses of Some Novel 1,3,4-Oxadiazole Derivatives and their Potential Biological Activity. Asian J. Research Chem. 6(2): February 2013; Page 97-100.

Cite(Electronic):
Freddy H. Havaldar, Azadkumar S. Sharma. Syntheses of Some Novel 1,3,4-Oxadiazole Derivatives and their Potential Biological Activity. Asian J. Research Chem. 6(2): February 2013; Page 97-100.   Available on: https://ajrconline.org/AbstractView.aspx?PID=2013-6-2-1


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