Asian Journal of Research in Chemistry

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0974-4150 (Online)
0974-4169 (Print)


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Syntheses of Some Novel 1,3,4-Oxadiazole Derivatives and their Potential Biological Activity

Author(s): Freddy H. Havaldar, Azadkumar S. Sharma

Email(s): azadsharma83@gmail.com

DOI: Not Available

Address: Freddy H. Havaldar* and Azadkumar S. Sharma
Nadkarny-Sacasa Research Laboratory, Department of Chemistry, St. Xavier’s College, Mumbai - 400 001.
*Corresponding Author

Published In:   Volume - 6,      Issue - 2,     Year - 2013

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ABSTRACT:
A new Mannich base of quinazolin-4-one derivatives possessing 1,3,4-oxadiazole ring have been synthesized by reacting 3-[4-(5-thioxo-4,5-dihydro-[1,3,4]oxadiazole-2-yl)-phenyl]-2-phenyl-3H-quinazolin-4-one (4) with different secondary amines and formaldehyde using N,N-dimethylformamide as the solvent to afford 3-[4-(4-substituted amino-4-ylmethyl-5-thioxo-4,5-dihydro-[1,3,4]oxadiazole-2-yl)-phenyl]-2-phenyl-3H-quinazolin-4-ones (5a-e). The structures of the newly synthesized compounds have been established by analytical and spectral methods. The compounds have also been screened for their biological activity.


Keywords:

Cite this article:
Freddy H. Havaldar, Azadkumar S. Sharma. Syntheses of Some Novel 1,3,4-Oxadiazole Derivatives and their Potential Biological Activity. Asian J. Research Chem. 6(2): February 2013; Page 97-100.

Cite(Electronic):
Freddy H. Havaldar, Azadkumar S. Sharma. Syntheses of Some Novel 1,3,4-Oxadiazole Derivatives and their Potential Biological Activity. Asian J. Research Chem. 6(2): February 2013; Page 97-100.   Available on: https://ajrconline.org/AbstractView.aspx?PID=2013-6-2-1


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Asian Journal of Research in Chemistry (AJRC) is an international, peer-reviewed journal devoted to pure and applied chemistry..... Read more >>>

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Asian Journal of Research in Chemistry (AJRC) (ISSN: print-0974-4169, Online-0974-4150) is an international, peer-reviewed journal devoted to pure and applied chemistry. AJRC publishes Original Research Articles, Short Communications, Review Articles in all aspects of chemistry. Topics covered including the traditional areas of analytical, inorganic, organic, biochemistry, forensic, physical-theoretical chemistry as well as newer interdisciplinary areas such as agriculture, materials science, computational, medicine, spectroscopy, polymers, supramolecular, surface, chemical physics, biological, medicinal/ drugs, environmental and pharmaceutical chemistry.
The journal is published quarterly every year in last week of March, June, September and December. From January 2011, is monthly and shall be published every year in last week of Month.    
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