An efficient synthesis of different novel 4,5–diphenyl pyrrole derivatives by the paal- knorr condensation has been accomplished using substituted aniline and 1,4 – diketone. The synthesized compounds were confirmed through spectral characterization using IR, 1H NMR. The pyrrole derivatives examined for their in vitro antimicrobial activity and in vivo anti- inflammatory. Result indicated that these compounds showed promising anti microbial and anti- inflammatory activity in comparison to amoxicillin and ibuprofen (the standard antimicrobial and anti–inflammatory drugs). Tolmetin (Rumatol) and Ketorolac (Ketolac), nonsteroidal anti-inflammatory drugs (NSAIDs) containing pyrrole ring, are nonselective inhibitors of cyclooxygenase 1 and 2 enzymes that led to decrease prostaglandin synthesis.
Cite this article:
Dipali Uthale, S. K. Mohite. Synthesis and Anti-Inflammatory Activity of Some 4,5 Diphenyl Pyrrole Derivatives. Asian J. Research Chem 7(1): January 2014; Page 58-61.