Asian Journal of Research in Chemistry

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0974-4150 (Online)
0974-4169 (Print)


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Synthesis and Anti-Inflammatory Activity of Some 4,5 Diphenyl Pyrrole Derivatives

Author(s): Dipali Uthale, S. K. Mohite

Email(s): deep9225@yahoo.in

DOI: Not Available

Address: Dipali Uthale*, Dr. S. K. Mohite
Rajarambapu College of Pharmacy, Kasegaon-415409, Maharashtra, India.
*Corresponding Author

Published In:   Volume - 7,      Issue - 1,     Year - 2014

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ABSTRACT:
An efficient synthesis of different novel 4,5–diphenyl pyrrole derivatives by the paal- knorr condensation has been accomplished using substituted aniline and 1,4 – diketone. The synthesized compounds were confirmed through spectral characterization using IR, 1H NMR. The pyrrole derivatives examined for their in vitro antimicrobial activity and in vivo anti- inflammatory. Result indicated that these compounds showed promising anti microbial and anti- inflammatory activity in comparison to amoxicillin and ibuprofen (the standard antimicrobial and anti–inflammatory drugs). Tolmetin (Rumatol) and Ketorolac (Ketolac), nonsteroidal anti-inflammatory drugs (NSAIDs) containing pyrrole ring, are nonselective inhibitors of cyclooxygenase 1 and 2 enzymes that led to decrease prostaglandin synthesis.


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Cite this article:
Dipali Uthale, S. K. Mohite. Synthesis and Anti-Inflammatory Activity of Some 4,5 Diphenyl Pyrrole Derivatives. Asian J. Research Chem 7(1): January 2014; Page 58-61.

Cite(Electronic):
Dipali Uthale, S. K. Mohite. Synthesis and Anti-Inflammatory Activity of Some 4,5 Diphenyl Pyrrole Derivatives. Asian J. Research Chem 7(1): January 2014; Page 58-61.   Available on: https://ajrconline.org/AbstractView.aspx?PID=2014-7-1-11


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Asian Journal of Research in Chemistry (AJRC) (ISSN: print-0974-4169, Online-0974-4150) is an international, peer-reviewed journal devoted to pure and applied chemistry. AJRC publishes Original Research Articles, Short Communications, Review Articles in all aspects of chemistry. Topics covered including the traditional areas of analytical, inorganic, organic, biochemistry, forensic, physical-theoretical chemistry as well as newer interdisciplinary areas such as agriculture, materials science, computational, medicine, spectroscopy, polymers, supramolecular, surface, chemical physics, biological, medicinal/ drugs, environmental and pharmaceutical chemistry.
The journal is published quarterly every year in last week of March, June, September and December. From January 2011, is monthly and shall be published every year in last week of Month.    
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