ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): Anuruddha R. Chabukswar, Vishakha G. Thakur, Priyanka V. Kandale, Shailesh N. Sharma, Bhanudas S. Kuchekar, Viplav N. Sonawane

Email(s): anichem18@gmail.com

DOI: Not Available

Address: Anuruddha R. Chabukswar*, Vishakha G. Thakur, Priyanka V. Kandale, Shailesh N. Sharma, Bhanudas S. Kuchekar, Viplav N. Sonawane
Maharashtra Academy of Engineering and Educational Research’s, Maharashtra Institute of Pharmacy, MIT Campus, Paud road, Kothrud, Pune - 411038, Maharashtra, India.
*Corresponding Author

Published In:   Volume - 7,      Issue - 12,     Year - 2014


ABSTRACT:
A simple, sensitive, precise, rapid and accurate UV spectrophotometric method have been developed for simultaneous estimation of Paracetamol (PARA), Ibuprofen (IBU) and Caffeine (CAFF) in combined pharmaceutical dosage forms. This ternary mixture was analysed using Ratio-derivative method. Methanol was used as solvent. The amplitudes of PARA, IBU and CAFF were measured at 213.89 nm, 213.14 nm and 268.46 nm respectively. Beer-Lambert’s law is obeyed in the concentration range of 6.5-32.5 µg/mL for PARA, 8-40 µg/mL IBU and 0.5-2.5 µg/mL for CAFF. By proposed method the % assay in commercial formulation was found to be in the range of 98.86-99.67% for PARA 99.25-100.51% for IBU and 98.23-98.85% CAFF. Recovery was found to be in the range of 98.22-100.57% for PARA, 98.34-101.75% for IBU and 98.15-99.25 % CAFF. This proposed method was validated with respect to linearity, precision, accuracy, limit of detection and limit of quantitation. This method was successfully applied for the analysis of commercial formulation (IMOL PLUS tablet). It was found that there was no interference by excipients as indicated by the recovery study results and therefore this method can be used in the quality control of formulation containing PARA, IBU and CAFF in combined dosage form.


Cite this article:
Anuruddha R. Chabukswar, Vishakha G. Thakur, Priyanka V. Kandale, Shailesh N. Sharma, Bhanudas S. Kuchekar, Viplav N. Sonawane. Development and Validation of UV-Spectrophotometric Method for the Simultaneous Determination of Paracetamol, Ibuprofen and Caffeine in Pharmaceutical Dosage Form. Asian J. Research Chem. 7(12): December, 2014; Page 1019-1022.

Cite(Electronic):
Anuruddha R. Chabukswar, Vishakha G. Thakur, Priyanka V. Kandale, Shailesh N. Sharma, Bhanudas S. Kuchekar, Viplav N. Sonawane. Development and Validation of UV-Spectrophotometric Method for the Simultaneous Determination of Paracetamol, Ibuprofen and Caffeine in Pharmaceutical Dosage Form. Asian J. Research Chem. 7(12): December, 2014; Page 1019-1022.   Available on: https://ajrconline.org/AbstractView.aspx?PID=2014-7-12-3


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DOI: 10.5958/0974-4150 

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