ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): K. Hanumantha Rao, A. Lakshmana Rao, K.B. Chandra Sekhar

Email(s): dralrao@gmail.com

DOI: Not Available

Address: K. Hanumantha Rao1, A. Lakshmana Rao2* and K.B. Chandra Sekhar3
1Department of Pharmacy, Krishna University, Machilipatnam- 521 001, A.P., India
2V. V. Institute of Pharmaceutical Sciences, Gudlavalleru- 521 356, A.P., India.
3Departement of Chemistry, JNTUA, Anantapuramu- 515 002, A.P., India.
*Corresponding Author

Published In:   Volume - 7,      Issue - 4,     Year - 2014


ABSTRACT:
A simple, rapid, sensitive, accurate and precise RP-HPLC method has been developed and validated for the estimation of Paroxetine in bulk and pharmaceutical dosage forms. The method was carried out using Inertsil ODS C18 (150 x 4.6 mm I.D., 5 µm particle size) column and mobile phase comprised of phosphate buffer pH 2.6 and acetonitrile in proportion of ratio 70:30 v/v and degassed in ultrasonic water bath. The flow rate was 1.0 mL/min and the detection wavelength was at 211 nm. The linearity was observed in the range of 25-150 µg/mL with a correlation coefficient of 0.999. The retention time of Paroxetine was 3.276 min. The method was validated as per the ICH guidelines for its linearity, precision, accuracy, specificity, limit of detection, limit of quantitation and by performing recovery studies. The percentage recovery of the drug Paroxetine was 99.41 % to 99.93 % from the tablet formulation. The proposed method is suitable for the routine quality control analysis for the estimation of Paroxetine in bulk and pharmaceutical dosage forms.


Cite this article:
K. Hanumantha Rao, A. Lakshmana Rao, K.B. Chandra Sekhar. Reverse Phase High Performance Liquid Chromatographic Method for the Analysis of Paroxetine in Pharmaceutical Dosage Forms. Asian J. Research Chem. 7(4): April 2014; Page 397-400.


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