Asian Journal of Research in Chemistry

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0974-4150 (Online)
0974-4169 (Print)


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Simultaneous Determination of Paracetamol and Caffeine in tablets by Mean Centering and Derivative Transforms of UV Ratio Spectra

Author(s): Vu Dang Hoang

Email(s): hoangvd@hup.edu.vn

DOI: Not Available

Address: Vu Dang Hoang
Department of Analytical Chemistry and Toxicology, Hanoi University of Pharmacy, 13-15 Le Thanh Tong, Hanoi, Vietnam
*Corresponding Author

Published In:   Volume - 7,      Issue - 6,     Year - 2014

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ABSTRACT:
Mean centering and first derivative transforms of UV ratio spectra were developed to resolve strongly overlapping spectra of paracetamol and caffeine in binary mixtures. Paracetamol 25 mg/L and caffeine 3.25 mg/L were identified as suitable divisors to obtain highest spectral recovery. The calibration graphs were recorded in phosphate buffer pH 7.2 for paracetamol (10–35 mg/L) and caffeine (2.4 – 4.4 mg/L). These spectrophotometric methods were successfully applied to the simultaneous determination of paracetamol and caffeine in commercially available tablets. They were also more sensitive than previously reported spectrophotometric method. No significant difference in accuracy and precision was observed for the proposed methods and official USP-HPLC.


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Cite this article:
Vu Dang Hoang. Simultaneous Determination of Paracetamol and Caffeine in tablets by Mean Centering and Derivative Transforms of UV Ratio Spectra. Asian J. Research Chem. 7(6): June 2014; Page 561-564.


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Asian Journal of Research in Chemistry (AJRC) (ISSN: print-0974-4169, Online-0974-4150) is an international, peer-reviewed journal devoted to pure and applied chemistry. AJRC publishes Original Research Articles, Short Communications, Review Articles in all aspects of chemistry. Topics covered including the traditional areas of analytical, inorganic, organic, biochemistry, forensic, physical-theoretical chemistry as well as newer interdisciplinary areas such as agriculture, materials science, computational, medicine, spectroscopy, polymers, supramolecular, surface, chemical physics, biological, medicinal/ drugs, environmental and pharmaceutical chemistry.
The journal is published quarterly every year in last week of March, June, September and December. From January 2011, is monthly and shall be published every year in last week of Month.    
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