ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): K. Vijaya Sri, G. Vinay Jain, M. Madhuri

Email(s): vijayasree_2002@yahoo.co.in

DOI: Not Available

Address: K. Vijaya Sri*, G. Vinay Jain, M. Madhuri
Department of Pharmaceutical Analysis, Malla Reddy College of Pharmacy, Maisammaguda, Secunderabad-500 014, Andhra Pradesh, India.
*Corresponding Author

Published In:   Volume - 7,      Issue - 8,     Year - 2014


ABSTRACT:
To develop a simple, fast and reliable derivative spectrophotometric methods for the estimation of rilpivirine hydrochloride in bulk and pharmaceutical dosage forms. The solutions of standard and the sample were prepared in methanol and water (8:2). The quantitative determination of the drug was carried out using the zero order derivative values measured at 305nm and the first order derivative values measured at 271 nm (n=6). Linearity in the concentration range of 0.5–3.5 µg/ml and absorbance was measured at 305 nm and 271nm (r² = 0.999 and r² = 0.999) for zero order and first order derivative spectrophotometric method. All the proposed methods have been extensively validated as per ICH guidelines. There was no much significant difference between the performance of the proposed methods regarding the mean values and standard deviations. Developed spectrophotometric methods in this study are simple, accurate, precise, sensitive to assay of rilpivirine hydrochloride in pharmaceutical dosage form.


Cite this article:
K. Vijaya Sri, G. Vinay Jain, M. Madhuri. Zero Order and First Order Derivative Spectrophotometric Method for Determination of Rilpivirine Hydrochloride in Bulk Drug and Pharmaceutical Dosage Form. Asian J. Research Chem. 7(8): August 2014; Page 717-721.


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DOI: 10.5958/0974-4150 

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