ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): Mohammad Yunoos, G. Saravanan, M. Sowjanya, B. Raju, R. Adi Narayana

Email(s): yunoosvja@gmail.com

DOI: Not Available

Address: Mohammad Yunoos*, G. Saravanan, M. Sowjanya, B. Raju, R. Adi Narayana
Department of Pharmaceutical Analysis, Bapatla College of Pharmacy, Bapatla-5222101, Andhra Pradesh, India
*Corresponding Author

Published In:   Volume - 7,      Issue - 8,     Year - 2014


ABSTRACT:
A simple, accurate, rapid and sensitive UV spectrophotometric method has been developed for the estimation of Alosetron hydrochloride (AST) in bulk as well as in Pharmaceutical dosage forms. Alosetron hydrochloride is used as anti-diarrhoeal agent. It is available in the market in tablet dosage forms with strength 0.5mg and 1mg . The present research work involves the estimation of Alosetron hydrochloride using double distilled water as solvent. An absorption maximum (? max) was found to be 218 nm. It obeys the beer’s law in the concentration range of 2-10 µg/ml with a correlation coefficient value of 0.9994. Validation of the method has been carried out statistically as per ICH guidelines and the results were found to be satisfactory. The result of mean % recovery was found to be 100.28 + 0.69 % for Alosetron hydrochloride which shows that the method was not affected by the presence of common excipients in tablet dosage form. The % RSD for both inter-day and intra-day precision was found to be less than 2%. The limit of detection (LOD) and limit of quantification (LOQ) was found to be 0.1015 µg/mL and 0.3078 µg/mL. The method was validated by determining its sensitivity, linearity, accuracy and precision which proves suitability of the developed method for the routine quality control analysis for the estimation of Alosetron hydrochloride in bulk and tablet dosage form.


Cite this article:
Mohammad Yunoos, G. Saravanan, M. Sowjanya, B. Raju, R. Adi Narayana. A Validated Simple UV Spectrophotometric Method for the Estimation of Alosetron Hydrochloride in Bulk and Pharmaceutical Dosage Form. Asian J. Research Chem. 7(8): August 2014; Page 748-750.

Cite(Electronic):
Mohammad Yunoos, G. Saravanan, M. Sowjanya, B. Raju, R. Adi Narayana. A Validated Simple UV Spectrophotometric Method for the Estimation of Alosetron Hydrochloride in Bulk and Pharmaceutical Dosage Form. Asian J. Research Chem. 7(8): August 2014; Page 748-750.   Available on: https://ajrconline.org/AbstractView.aspx?PID=2014-7-8-9


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