Nachiket S. Dighe, Renuka N.Barhate, Ravindra B. Lawre, Sunil A. Nirmal
Nachiket S. Dighe1*, Renuka N.Barhate1, Ravindra B. Lawre2, Sunil A. Nirmal3
1Department of Pharmaceutical Chemistry, Pravara Rural College of Pharmacy, Loni, MS, India-413736
2Department of Pharmaceutics, Pravara Rural College of Pharmacy, Loni, MS, India-413736
3Department of Pharmacology, Pravara Rural College of Pharmacy, Loni, MS, India-413736
Volume - 8,
Issue - 12,
Year - 2015
This study was designed to synthesize, characterize and to evaluate the pharmacological activity of substituted phenothiazine derivatives. Totally thirteen compounds, were synthesized by conventional method. Purity of the synthesized compounds was ascertained by TLC and melting point determination by open capillary tube method and they were characterized by IR and NMR spectroscopic methods. Antidepressant activity of all the synthesized compounds was evaluated by despair swim test by using Sprague Dawley Rats. Standard drug Imipramine was used as the control. In the results of the spectral study. all the compounds showed characteristic peak in IR and NMR spectroscopy. In the despair swim test, all the synthesized derivatives showed antidepressant activity. Among them three Compounds (A1, A3 A6 and A8) showed significant antidepressant activity comparing with control drug imipramine. These results are useful for the further investigation in the future.
Cite this article:
Nachiket S. Dighe, Renuka N.Barhate, Ravindra B. Lawre, Sunil A. Nirmal. Synthesis and Evaluation of Phenothiazine derivative for Anti-depressant activity. Asian J. Research Chem. 8(12): December 2015; Page 745-750. doi: 10.5958/0974-4150.2015.00120.