ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): Rele Rajan V., Rane Dattaprasad G.

Email(s): drvinraj@gmail.com

DOI: 10.5958/0974-4150.2017.00004.9   

Address: Rele Rajan V.*, Rane Dattaprasad G.
Department of Chemistry D.G. Ruparel College Mahim Mumbai 400016
*Corresponding Author

Published In:   Volume - 10,      Issue - 1,     Year - 2017


ABSTRACT:
A simple precise, rapid accurate and sensitive non-aqueous potentiometric titration method was developed for quantitative determination of clopidogrel bisulphate from pharmaceutical dosage form. The titration was carried out using standardized 0.1 N perchloric acid. The proposed method was found to be precise with % RSD <1 (n = 6). The method showed strict linearity (r2 > 0.9999) between 20 % to 100 % of 0.100 mg of drug substance weight. The percentage recovery of clopidogrel bisulphate in the optimized method was between 100.0 to 100.416 %. The method is also found to be rugged when checked by different analysts and using different lots of reagents and different makes of titrators.


Cite this article:
Rele Rajan V., Rane Dattaprasad G.. A Validated Non-Aqueous Potentiometric Titration Method for Quantitative Determination of Clopidogrel bisulphate from Pharmaceutical Preparation. Asian J. Research Chem. 2017; 10(1):26-28. doi: 10.5958/0974-4150.2017.00004.9


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DOI: 10.5958/0974-4150 

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