Author(s):
Siddhartha Marupati, Laxminarayana Eppakayala, Ramesh Malothu, Ramchander Merugu, Venkat Reddy Pendyala
Email(s):
elxnkits@yahoo.co.in
DOI:
10.5958/0974-4150.2017.00099.2 
Address:
Siddhartha Marupati1, Laxminarayana Eppakayala2*, Ramesh Malothu3,
Ramchander Merugu4,Venkat Reddy Pendyala2
1Vardhaman College of Engineering, Shamshabad, Hyderabad 500 018, Telangana, India.
2Sreenidhi Institute of Science and Technology (Autonomous) Yamnampet, Ghatkesar, Hyderabad- 501301, Telangana, India
3Jawaharlal Nehru Technological University, Kakinada-533 003, Andhra Pradesh, India
4University College of Science, Mahatma Gandhi University, Nalgonda-508254, Telangana, India
*Corresponding Author
Published In:
Volume - 10,
Issue - 4,
Year - 2017
ABSTRACT:
5-Aryl-5,6-dihydro-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(4H)-ones (2a-e) were synthesized by the condensation of 4-amino-1-methyl-3-propyl-1H-pyrazole-5-carboxamide with different aldehydes using microwave irradiation. All title compounds were characterized by 1H NMR and massspectra. Molecular docking of 5cox with ligand showed that the title compound was a potent anti-inflammatory compound.
Cite this article:
Siddhartha Marupati, Laxminarayana Eppakayala, Ramesh Malothu, Ramchander Merugu, Venkat Reddy Pendyala. Microwave assisted facile synthesis of 5-Aryl-5, 6-dihydro-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(4H)-ones and docking for anti-inflammatory activity. Asian J. Research Chem. 2017; 10(4):593-596. doi: 10.5958/0974-4150.2017.00099.2
Cite(Electronic):
Siddhartha Marupati, Laxminarayana Eppakayala, Ramesh Malothu, Ramchander Merugu, Venkat Reddy Pendyala. Microwave assisted facile synthesis of 5-Aryl-5, 6-dihydro-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(4H)-ones and docking for anti-inflammatory activity. Asian J. Research Chem. 2017; 10(4):593-596. doi: 10.5958/0974-4150.2017.00099.2 Available on: https://ajrconline.org/AbstractView.aspx?PID=2017-10-4-30