ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): Shankaraiah Malthum, Venkanna Banothu, Jaya Shree Anireddy

Email(s): shankar.malthum@gmail.com

DOI: 10.5958/0974-4150.2018.00029.9   

Address: Shankaraiah Malthum1, Venkanna Banothu2, Jaya Shree Anireddy1*
1Centre for Chemical Sciences and Technology, IST, Jawaharlal Nehru Technological University Hyderabad, Kukatpally, Hyderabad 500085, Telangana State, India
2Center for Biotechnology, IST, JNTUH, Kukatpally, Hyderabad-500085, India
*CorrespondingAuthor

Published In:   Volume - 11,      Issue - 1,     Year - 2018


ABSTRACT:
An efficient and inexpensive approach to the synthesis of 2-substituted 1, 3, 4- oxadiazoles from arylhydrazides and orthoester is reported using catalytic PTSA. The optimized reaction is performed using catalytic PTSA in EtOH and is complete within 1 h for non aromatic orthoesters and 2-30 h for aromatic orthoesters. The reaction permits both electron releasing and electron withdrawing groups on the arylhydrazide substrate. Most products formed in high yield and require only minimal purification. The reaction proceeded smoothly and cleanly under mild reaction conditions and no side reactions were observed. The structures of the products were confirmed by IR, 1H NMR, 13C NMR, mass spectroscopy, and elemental analysis. Compared with early reports, the current reactions proceed in shorter time and require less of the orthoester.


Cite this article:
Shankaraiah Malthum, Venkanna Banothu, Jaya Shree Anireddy. Synthesis of 1, 3, 4-Oxadiazole of NSAIDs and their Biological Properties. Asian J. Research Chem. 2018; 11(1):139-142. doi: 10.5958/0974-4150.2018.00029.9

Cite(Electronic):
Shankaraiah Malthum, Venkanna Banothu, Jaya Shree Anireddy. Synthesis of 1, 3, 4-Oxadiazole of NSAIDs and their Biological Properties. Asian J. Research Chem. 2018; 11(1):139-142. doi: 10.5958/0974-4150.2018.00029.9   Available on: https://ajrconline.org/AbstractView.aspx?PID=2018-11-1-29


Recomonded Articles:

Author(s): Gullipilli Sandhya, R. Ravichandra Babu

DOI: 10.5958/0974-4150.2018.00115.3         Access: Open Access Read More

Author(s): Kateryna Taran, Ayaou Abderrahim, Vera Kravchenko, Olena Novosel, Svitlana Taran

DOI: 10.5958/0974-4150.2020.00034.6         Access: Open Access Read More

Author(s): Ram C. Senwar, Krishna K. Rathore, Anita Mehta

DOI: 10.5958/0974-4150.2017.00022.0         Access: Open Access Read More

Author(s): Virupakshi Prabhakar, Kondra Sudhakar Babu, L.K. Ravindranath, M. Sahanoor Basha, J. Latha

DOI: 10.5958/0974-4150.2017.00012.8         Access: Open Access Read More

Author(s): Prathima Patil, S.P. Sethy, T. Sameena, K. Shailaja

DOI:         Access: Open Access Read More

Author(s): Arun Kumar, Vinita Gupta, Sanchita Singh, Y.K. Gupta

DOI: 10.5958/0974-4150.2017.00038.4         Access: Open Access Read More

Author(s): Bulusu Lakshmi Sushma1, Gutta Madhusudhan, Anireddy Jayashree

DOI: 10.5958/0974-4150.2017.00014.1         Access: Open Access Read More

Author(s): Y. Padmavathi, Akari Anjali, Nayaka Raghavendra Babu, P Ravi Kumar

DOI: 10.5958/0974-4150.2017.00064.5         Access: Open Access Read More

Author(s): Tauseef Shaikh, Atar Mujum , Khan Wasimuzzama, Rukhsana A Rub

DOI:         Access: Open Access Read More

Author(s): Vatchavai Bhaskara Raju, Bonthu Mohan Gandhi, Kamatham Srinivas Sumanth, Kolli Srinivas, Tupakula N Venkata Lakshmi Neeraja

DOI: 10.5958/0974-4150.2017.00030.X         Access: Open Access Read More

Author(s): SS Chitlange, Kiran Bagri, DM Sakarkar

DOI:         Access: Open Access Read More

Asian Journal of Research in Chemistry (AJRC) is an international, peer-reviewed journal devoted to pure and applied chemistry..... Read more >>>

RNI: Not Available                     
DOI: 10.5958/0974-4150 

Popular Articles


Recent Articles




Tags