Asian Journal of Research in Chemistry

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0974-4150 (Online)
0974-4169 (Print)


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A non-Aqueous Potentiometric Titration Method for Validation of Secnidazole from Pharmaceutical Dosages

Author(s): Rajan V. Rele

Email(s): drvinraj@gmail.com

DOI: 10.5958/0974-4150.2019.00006.3   

Address: Rajan V. Rele*
Department of Chemistry, D. G. Ruparel College, Mahim, Mumbai 400016.
*Corresponding Author

Published In:   Volume - 12,      Issue - 1,     Year - 2019

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ABSTRACT:
A sensitive non-aqueous potentiometric titration method was developed for quantitative determination of secnidazole from pharmaceutical dosage form. The titration was carried out using standardized 0.1 N perchloric acid. The proposed method was found to be precise with % RSD <1 (n = 6). The method showed strict linearity (r2> 0.999) between 20 % to 100 % of 500 mg of drug substance weight. The percentage recovery of secnidazole in the optimized method was between 99.643 to 100.505 %. The method is also found to be rugged when checked by different analysts and using different lots of reagents and different makes of titrators.


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Cite this article:
Rajan V. Rele. A non-Aqueous Potentiometric Titration Method for Validation of Secnidazole from Pharmaceutical Dosages. Asian J. Research Chem. 2019; 12(1): 25-28. doi: 10.5958/0974-4150.2019.00006.3

Cite(Electronic):
Rajan V. Rele. A non-Aqueous Potentiometric Titration Method for Validation of Secnidazole from Pharmaceutical Dosages. Asian J. Research Chem. 2019; 12(1): 25-28. doi: 10.5958/0974-4150.2019.00006.3   Available on: https://ajrconline.org/AbstractView.aspx?PID=2019-12-1-6


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Asian Journal of Research in Chemistry (AJRC) is an international, peer-reviewed journal devoted to pure and applied chemistry..... Read more >>>

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Asian Journal of Research in Chemistry (AJRC) (ISSN: print-0974-4169, Online-0974-4150) is an international, peer-reviewed journal devoted to pure and applied chemistry. AJRC publishes Original Research Articles, Short Communications, Review Articles in all aspects of chemistry. Topics covered including the traditional areas of analytical, inorganic, organic, biochemistry, forensic, physical-theoretical chemistry as well as newer interdisciplinary areas such as agriculture, materials science, computational, medicine, spectroscopy, polymers, supramolecular, surface, chemical physics, biological, medicinal/ drugs, environmental and pharmaceutical chemistry.
The journal is published quarterly every year in last week of March, June, September and December. From January 2011, is monthly and shall be published every year in last week of Month.    
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