A simple precise, rapid accurate and sensitive non-aqueous potentiometric titration method was developed for quantitative determination of imatinib mesylate from pharmaceutical dosage form. The titration was carried out using standardized 0.1 N perchloric acid. The proposed method was found to be precise with % RSD <1 (n = 6). The method showed strict linearity (r2 > 0.999) between 20 % to 100 % of 500 mg of drug substance weight. The percentage recovery of imatinib mesylate in the optimized method was between 100.087 to 100.692 %. The method is also found to be rugged when checked by different analysts and using different lots of reagents and different makes of titrators.
Cite this article:
Rajan V. Rele, Pratamesh, P. Tiwatane. A Non-aqueous Potentiometric Titration Method for Validation of Imatinib mesylate from Pharmaceutical Dosages. Asian J. Research Chem. 2019; 12(6):307-310. doi: 10.5958/0974-4150.2019.00056.7