ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): Jignesh P Raval, Hemul V Patel, Pradip S. Patel, Nilesh H Patel, Kishor R Desai

Email(s): drjpraval@yahoo.co.in , drjpraval@hotmail.com

DOI: Not Available

Address: Jignesh P Raval1*, Hemul V Patel1, Pradip S. Patel1, Nilesh H Patel1 and Kishor R Desai2
1Department of Pharmaceutical Chemistry, Ashok and Rita Patel Institute of Integrated Study and Research in Biotechnology and Allied Sciences, New Vallabh vidyanagar (Gujarat-India)
2Department of Chemistry, Veer Narmad South Gujarat University, Udhna-Magdalla Road, Surat (Gujarat-India)
*Corresponding Author

Published In:   Volume - 2,      Issue - 2,     Year - 2009


ABSTRACT:
We report efficient and extremely fast procedures for the synthesis of 3-chloro-4-(4-(diethylamino)-2-hydroxyphenyl)-1-(substitutedphenyl)-azetidin-2-one using 4-diethylamino-2-hydroxybenzaldehyde, various amines and chloroacetyl chloride in presence of triethylamine under microwave irradiation (µw) and similarly, conventional methods are used for comparison. A considerable increase in the reaction rate has been observed with better yield in microwave technique. The structures of the compounds were confirmed by elemental analysis and spectral analysis (1H-NMR, 13C-NMR and Mass). All the compounds have been screened for their antifungal activity and their antibacterial activity against various gram +ve and gram –ve bacteria.


Cite this article:
Jignesh P Raval, Hemul V Patel, Pradip S. Patel, Nilesh H Patel, Kishor R Desai. A Rapid, Convenient Microwave assisted and Conventional Synthesis of novel azetidin-2-one derivatives as Potent Antimicrobial agents. Asian J. Research Chem. 2(2): April.-June, 2009 page 171-177.


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