ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): Rele Rajan V., Tiwatane Prathamesh P.

Email(s): drvinraj@gmail.com

DOI: 10.5958/0974-4150.2020.00082.6   

Address: Rele Rajan V.*, Tiwatane Prathamesh P.
Central Research Laboratory, D.G. Ruparel College Mahim, Mumbai, 400016.
*Corresponding Author

Published In:   Volume - 13,      Issue - 6,     Year - 2020


ABSTRACT:
A simple precise, rapid accurate and sensitive non-aqueous potentiometric titration method was developed for quantitative determination of isoxsuprine hydrochloride from pharmaceutical dosage form. The titration was carried out using standardized 0.1 N perchloric acid. The proposed method was found to be precise with %RSD <1 (n = 6). The method showed strict linearity (r2 > 0.9999) between 10% to 50% of 0.500mg of drug substance weight. The percentage recovery of isoxsuprine hydrochloride in the optimized method was between 98.66 to 99.95%. The method is also found to be rugged when checked by different analysts and using different lots of reagents and different makes of titrators.


Cite this article:
Rele Rajan V., Tiwatane Prathamesh P. A Validated Potentiometric titration method for Quantitative Determination of Isoxsuprine hydrochloride from Pharmaceutical Preparation. Asian J. Research Chem. 2020; 13(6):465-468. doi: 10.5958/0974-4150.2020.00082.6


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