ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): Abhishek Chaudhary, Divya Arora, Pooja Devi

Email(s): dvarora50@gmail.com

DOI: 10.52711/0974-4150.2022.00084   

Address: Abhishek Chaudhary, Divya Arora*, Pooja Devi
Abhilashi University, Chail Chowk, Tehsil Chachyot, Mandi, Himachal Pradesh - 175028, India.
*Corresponding Author

Published In:   Volume - 15,      Issue - 6,     Year - 2022


ABSTRACT:
As we know, there is tremendous cases of neuropathic pain seen recently in the world. Due to the toxic effects of drugs used to reduce this severe dysfunction, one can always move towards the herbal products or substances available in nature. Nature has numerous drugs that can be used to cure even severe diseases. One of which is Capsaicin which is available in the Capsicum or pepper. This Capsaicin plays a vital role in the treatment of neuropathic pain. In this article, we will discuss the roles and importance of Capsaicin (Pepper) found in Capsicum in neuropathic pain.


Cite this article:
Abhishek Chaudhary, Divya Arora, Pooja Devi. A Review on the role of Capsaicin in Neuropathic Pain. Asian Journal of Research in Chemistry. 2022; 15(6):495-8. doi: 10.52711/0974-4150.2022.00084

Cite(Electronic):
Abhishek Chaudhary, Divya Arora, Pooja Devi. A Review on the role of Capsaicin in Neuropathic Pain. Asian Journal of Research in Chemistry. 2022; 15(6):495-8. doi: 10.52711/0974-4150.2022.00084   Available on: https://ajrconline.org/AbstractView.aspx?PID=2022-15-6-16


REFERENCES:
1.    Hall OM. Broussard A. Range T. et al. Novel Agents in Neuropathic Pain, the Role of Capsaicin: Pharmacology, Efficacy, Side Effects, Different Preparations. Curr Pain Headache Rep.2020; 24:53.https://doi.org/10.1007/s11916-020-00886-4
2.    DiBonaventura MD. Sadosky A. Concialdi K. Hopps M. Kudel I. Parsons B. et al. The prevalence of probable neuropathic pain in the US: results from a multimodal general-population health survey. J Pain Res. 2017;10:2525–38. https://doi.org/10.2147/JPR.S127014
3.    Peppin JF. Pappagallo M. Capsaicinoids in the treatment of neuropathic pain: a review. Ther Adv Neurol Disord. 2014;7:22–32. https://doi.org/10.1177/1756285613501576.
4.    Laklouk M. Baranidharan G. Profile of the capsaicin 8% patch for the management of neuropathic pain associated with postherpetic neuralgia: safety, efficacy, and patient acceptability. Patient Prefer Adherence. 2016;10:1913–8. doi:https://doi.org/10.2147/PPA S76506Excellent review of the capsaicin patch in postherpetic neuralgia.
5.    Berman B. Lewith G. Manheimer E. Bishop FL. D’Adamo C. Complementary and alternative medicine. Rheumatology. 2015: 382–9. https://doi.org/10.1016/B978-0-323-09138-1.00048-6
6.    SMITH HS. Christo PJ. Cauley BD. Postherpetic neuralgia. Curr Ther Pain. 2009:261–7. https://doi.org/10.1016/B978-1-4160- 4836-7.00036-5
7.    Schumacher MA. Transient receptor potential channels in pain and inflammation: therapeutic opportunities. Pain Pract. 2010;10:185– 200. https://doi.org/10.1111/j.1533-2500.2010.00358.x
8.    Baranidharan G. Das S. Bhaskar A. A review of the highconcentration capsaicin patch and experience in its use in the management of neuropathic pain. Ther Adv Neurol Disord. 2013;6: 287–97. https://doi.org/10.1177/1756285613496862Excellent review of the capsaicin patch in neuropathic pain.
9.    Backonja M. Wallace MS. Blonsky ER. Cutler BJ. Malan P Jr. Rauck R. et al. NGX-4010, a high-concentration capsaicin patch, for the treatment of postherpetic neuralgia: a randomised, doubleblind study. Lancet Neurol. 2008;7:1106–12.
10.    Derry S. Moore AR. Topical capsaicin (low concentration) for chronic neuropathic pain in adults. Cochrane Database Syst Rev. 2012;9:CD010111. https://doi.org/10.1002/14651858.CD010111
11.    McCleane G. Topical analgesic agents. Clin Geriatr Med. 2008;24: 299–312. https://doi.org/10.1016/j.cger.2007.12.009
12.    Campbell BK. Fillingim RB. Lee S. Brao R. Price DD. Neubert JK. Effects of high-dose capsaicin on TMD subjects: a randomized clinical study. JDR Clin Transl Res. 2017;2:58–65.https://doi.org/10.1177/2380084416675837
13.    Watson CPN. Evans RJ. Watt VR. The post-mastectomy pain syndrome and the effect of topical capsaicin. Pain. 1989;38:177–86. https://doi.org/10.1016/0304-3959(89)90236-4
14.    Lysy J. Sistiery-Ittah M. Israelit Y. Shmueli A. Strauss-Liviatan N. Mindrul V. et al. Topical capsaicin - a novel and effective treatment for idiopathic intractable pruritus ani: a randomised, placebo controlled, crossover study. Gut. 2003;52:1323–6. https://doi.org/10. 1136/gut.52.9.1323
15.    Berger A. Henderson M. Nadoolman W. Duffy V. Cooper D. Saberski L. et al. Oral capsaicin provides temporary relief for oral mucositis pain secondary to chemotherapy/radiation therapy. J Pain Symptom Manag. 1995;10:243–8. https://doi.org/10.1016/0885-3924(94)00130-D
16.    Chang A. Quick J. Capsaicin. StatPearls, 2019, p. 6–9.
17.    Capsaicin (Zostrix) topical cream 2009.
18.    Qutenza (capsaicin) 8% topical patch package insert 2012.
19.    Capsaicin arthritis pain relief topical analgesic liquid package insert. 2011.
20.    Friedman JR. Nolan NA. Brown KC. Miles SL. Akers AT. Colclough KW. et al. Anticancer activity of natural and synthetic capsaicin analogs. J Pharmacol Exp Ther. 2018;364:462–73. https://doi.org/10.1124/jpet.117.243691
21.    Trevisani M. Szallasi A. Targeting TRPV1 : challenges and issues in pain management. Open Drug Discov J. 2010;2:37–49.
22.    Nolano M. Simone D. Wendelschafer-Crabb G. Johnson T. Hazen E. Kennedy W. Topical capsaicin in humans: parallel loss ofepidermal nerve fibers and pain sensation. Pain. 1999;81:135–45. https://doi.org/10.1016/S0304-3959(99)00007-X
23.    Kennedy WR. Vanhove GF. Ping LS. Tobias J. Bley KR. Walk D. et al. A randomized, controlled, open-label study of the long-term effects of NGX-4010, a high-concentration capsaicin patch, on epidermal nerve fiber density and sensory function in healthy volunteers. J Pain. 2010;11:579–87. https://doi.org/10.1016/j.jpain.2009. 09.019
24.    US National Library of Medicine. Resiniferatoxin to treat severe pain associated with advanced cancer. ClinicaltrialsGov 2008:12/1/2008–12/1/2014.
25.    National Drug Code Directory 2019.
26.    Pershing LK. Reilly CA. Corlett JL. Crouch DJ. Effects of vehicle on the uptake and elimination kinetics of capsaicinoids in human skin in vivo. Toxicol Appl Pharmacol. 2004;200:73–81. https://doi.org/10.1016/j.taap.2004.03.019
27.    Capsaicin (Professional Patient Advice) - Drugs 2019.
28.    López-Carrillo L. López-Cervantes M. Robles-Díaz G. RamírezEspitia A. Mohar-Betancourt A. Meneses-García A. et al. Capsaicin consumption, helicobacter pylori positivity and gastric cancer in Mexico. Int J Cancer. 2003;106:277–82.https://doi.org/10.1002/ijc.11195
29.    Qutenza 179mg cutaneous patch. Electron Med Compend 2019.
30.    Chanda S. Bashir M. Babbar S. Koganti A. Bley K. In vitro hepatic and skin metabolism of capsaicin. Drug Metab Dispos. 2008;36: 670–5. https://doi.org/10.1124/dmd.107.019240
31.    Qutenza 2009.
32.    Babbar S. Marier JF. Mouksassi MS. Beliveau M. Vanhove GF. Chanda S. et al. Pharmacokinetic analysis of cfapsaicin after topical administration of a high-concentration capsaicin patch to patients with peripheral neuropathic pain. Ther Drug Monit. 2009;31:502– 10. https://doi.org/10.1097/FTD.0b013e3181a8b200
33.    Suresh D. Srinivasan K. Tissue distribution & elimination of capsaicin, piperine & curcumin following oral intake in rats. Indian J Med Res. 2010;131:682–91.
34.    Chaiyasit K. Khovidhunkit W. Wittayalertpanya S. Pharmacokinetic and the effect of capsaicin in Capsicum frutescens on decreasing plasma glucose level. J Med Assoc Thail. 2009;92:108–13.
35.    Yost CAR. Yost GS. Metabolism of capsaicinoids by P450 enzymes. Drug Metab Rev. 2012;100:130–4. https://doi.org/10. 1016/j.pestbp.2011.02.012.Investigations
36.    Arnold JT. Stewart SB. Sammut L. Oral capsaicin ingestion : a brief update- dose , tolerance and side effects. Res Rev J Herb Sci. 2017;5.
37.    Stevens RM. Ervin J. Nezzer J. Nieves Y. Guedes K. Burges R. et al. Randomized, double-blind, placebo-controlled trial of intraarticular CNTX −4975 ( trans- capsaicin) for pain associated with osteoarthritis of the knee. Arthritis Rheumatol. 2019;71:1524–33. https://doi.org/10.1002/art.40894
38.    Campbell J. Stevens R. Hanson P. Therapeutics C. Characterization of the pharmacology and pharmacokinetics of Cntx-4975 , a highpurity , synthetic trans-capsaicin in clinical development for the treatment of moderate to severe OA knee pain [abstract]. Arthritis Rheumatol. 2018;70.
39.    Kawada T. Watanabe T. Katsura K. Takami H. Formation and metabolism of pungent principle of capsicum fruits : XV. Microdetermination of capsaicin by high-performance liquid chromatography with electrochemical detection. J Chromotography. 1985;329:99–105.
40.    Brock C, O’Neill J. Dickenson AH. Andresen T. Olesen AE. Nilsson M. Unravelling the mystery of capsaicin: a tool to understand and treat pain. Pharmacol Rev. 2012;64:939–71. https://doi.org/10.1124/pr.112.006163
41.    Rahman M. Alam K. Beg S. Anwar F. Kumar V. Liposomes as topical drug delivery systems: state of the arts: Elsevier Inc.; 2019. https://doi.org/10.1016/b978-0-12-816506-5.00004-8
42.    Duangjit S. Chairat W. Opanasopit P. Rojanarata T. Panomsuk S. Ngawhirunpat T. Development, characterization and skin interaction of capsaicin-loaded microemulsion-based nonionic surfactant. Biol Pharm Bull Pharm Bull. 2016;39:601–10. https://doi.org/10. 1248/bpb.b15-00961
43.    Ghiasi Z. Esmaeli F. Aghajani M. Ghazi-Khansari M. Faramarzi MA. Amani A. Enhancing analgesic and anti-inflammatory effects of capsaicin when loaded into olive oil nanoemulsion: an in vivo study. Int J Pharm. 2019;559:341–7. https://doi.org/10.1016/j. ijpharm.2019.01.043

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