Author(s):
Adinath R. Bhandwalakr, Rahul S. Bhondwe
Email(s):
adinathchems@gmail.com , rsbchem2020@gmail.com
DOI:
10.52711/0974-4150.2024.00053 
Address:
Adinath R. Bhandwalakr, Rahul S. Bhondwe
Tuljaram Chaturchand College, A/p-Karanje, Tal-Baramati, Dist-Pune, Someshwarnagar, 412306.
*Corresponding Author
Published In:
Volume - 17,
Issue - 6,
Year - 2024
ABSTRACT:
During the current study, the new synthesised aminothiophene, and it’s schiff base derivative were designed by reacting 2-amino-4,5,6,7-tetrahydrobenzo-(b)thiophene-3-carboxylate with different aldehyde in a good yield(65-70%).The new derivative characterised by various analytical, physical, biological and spectroscopic method (FT-IR,H1-NMR,and 13C-NMR method. The spectral of (FT-IR,¹H-NMR,¹³C-NMR) results suggest their geometry. The theoretically optimized structure were examined using Gaussion (R) 09 program Function of density function theory. Their bioactive nature designed by global reactivity parameter containing a high hardness (?) is 2.21 eV and lower softness (s) is 1.10 eV. ADME study of the tetrazole derivative (3), (6) and 4-formyl pyrrole respectively, which shows a bioactivity nature and lipinski rule of five which is developed to describe drug ability and oral bioavailability guidelines. The energy of LUMO linked with other activity.
Cite this article:
Adinath R. Bhandwalakr, Rahul S. Bhondwe. Aminothiophene and Schiff base derivative-synthesis, Density Functional theory, ADME study and it’s characterization. Asian Journal of Research in Chemistry.2024; 17(6):309-8. doi: 10.52711/0974-4150.2024.00053
Cite(Electronic):
Adinath R. Bhandwalakr, Rahul S. Bhondwe. Aminothiophene and Schiff base derivative-synthesis, Density Functional theory, ADME study and it’s characterization. Asian Journal of Research in Chemistry.2024; 17(6):309-8. doi: 10.52711/0974-4150.2024.00053 Available on: https://ajrconline.org/AbstractView.aspx?PID=2024-17-6-1
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