ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): Ismail, R Rajavel, M Ganesh, M Jagadeeswaran, K Srinivasan, J Valarmathi, T Sivakumar

Email(s): sivaecp@yahoo.com

DOI: Not Available

Address: Ismail*, R Rajavel, M Ganesh, M Jagadeeswaran, K Srinivasan, J Valarmathi and T Sivakumar
Nandha College of Pharmacy, Division of Pharmaceutical Analysis, Koorapalayam Pirivu, Erode- 638 052, Tamil Nadu, India
*Corresponding Author

Published In:   Volume - 1,      Issue - 1,     Year - 2008


ABSTRACT:
A simple, precise, accurate and rapid HPLC method has been developed, and validated for the determination of Aspirin, Atorvastatin and Pioglitazone simultaneously, in combined dosage form. Acetonitrile and phosphate buffer with pH 3.5 (40 %: 60 % v/v) is used as the mobile phase, 261nm is the detection wavelength for this study. The applicability of the method for simultaneous determination of Aspirin, Atorvastatin and Pioglitazone was verified by the determination of these compounds in marketed tablets. Results of the analysis were validated statistically, and by recovery studies (98.29 - 101.12 %). The recovery and RSD values within the limits given in ICH guide lines method developments indicates that the suitability of proposed methods for the routine determination of these compounds in tablets. The validation parameters: linearity (r > 0.996) , sensitivity (LOD (1.5- 0.7 x 10-4 mg ml-1 and LOQ % x 10-4 -1.05 x 10-4) , accuracy ( recoveries: 98.29 -101.12 % )and reproducibility were found to satisfactory. The proposed method can be successfully used to determine the drug contents of marketed formulation.


Cite this article:
Ismail, R Rajavel, M Ganesh, M Jagadeeswaran, K Srinivasan, J Valarmathi, T Sivakumar. RP-HPLC Method for the Simultaneous Determination of Aspirin, Atorvastatin and Pioglitazone in Capsule Dosage Form. Asian J. Research Chem. 1(1): July-Sept. 2008;Page 40-42.


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