ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): Rajesh Balkrishna Tawade, Abha Sham Dhomane

Email(s): tawade.rajesh@gmail.com

DOI: Not Available

Address: Rajesh Balkrishna Tawade, Dr. Abha Sham Dhomane
K.V. Pendharkar College, Dombivali, Mumbai, Maharashtra, India.
*Corresponding Author

Published In:   Volume - 6,      Issue - 11,     Year - 2013


ABSTRACT:
A high-performance liquid chromatographic method has been developed for the analysis of Ibandronic acid10 in solid dosage form1. The mobile phase consisting of EDTA and Hexane sulphonic acid buffer by adjusting pH (pH 2.5) and acetonitrile in ratio of (95:5 % v/v) was delivered at the flow rate of 1.0 mL/min and UV detection was carried out at 195 nm1. The separation was achieved using C18 reverse-phase column (250 X 4.6 mm I.D., particle size 5µm) 7 . The method was linear over the concentration range for Ibandronic acid. The analytical recovery obtained was 99.88%. The validation of method carried out as per ICH guidelines 4. The described HPLC method was successfully employed for the analysis of pharmaceutical formulations containing Ibandronic acid in solid dosage form and can be employed for bioequivalence study in future for the same formulations.


Cite this article:
Rajesh Balkrishna Tawade, Abha Sham Dhomane. Method Development and Validation for the Determination of Ibandronic Acid in Solid Dosage Form by RP-HPLC. Asian J. Research Chem. 6(11): November 2013; Page 1003-1006.


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