ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): Vimal I Patel, Harsha U Patel, Chhaganbhai N Patel, Kiran J Suthar

Email(s): patelvimal95@yahoo.com

DOI: Not Available

Address: Vimal I Patel*, Harsha U Patel, Chhaganbhai N Patel and Kiran J Suthar
Department of Pharmaceutical and Medicinal Chemistry, Shri Sarvajanik Pharmacy College, Hemchandracharya North Gujarat University, Near Arvind baug, Mehsana-384001, Gujarat, india
*Corresponding Author

Published In:   Volume - 2,      Issue - 4,     Year - 2009


ABSTRACT:
4-(4-Substituted Phenyl)-5,6-Disubstituted-1-(4-Substituted Phenyl Thiazol-2-yl)Pyridin-2(1H)-One have been prepared from citric acid.it is treated withconc.H2SO4 and then with phenetole to give ß-arylglutaconic acid which on fusion with 2-amino 4-substituted Phenyl thiazole results in 4-(4-substitutedphenyl)-1-(4-substitutedphenylthiazol-2-yl)pyridine-2,6(1H,3H)-dione. Then reacted with phosphorous oxychloride, it give 5,6-dichloro-4-(4-substituted phenyl)-1-(4substituted phenyl thiazol-2-yl) pyridin-2(1H)-one. Which on treatment with secondary amines Yields 4-(4-Substituted phenyl)-5,6-Disubstituted-1-(4-Substituted-Phenyl thiazol-2-yl)Pyridin-2(1H)-One.All the title compounds characterised on the basis of their IR, MASS, 1H NMR spectroscopic data analysis.


Cite this article:
Vimal I Patel, Harsha U Patel, Chhaganbhai N Patel, Kiran J Suthar. Synthesis and Anti-Bacterial Study of 4-(4-Substituted Phenyl)-5,6-Disubstituted-1- (4-Substituted Phenyl Thiazol-2-yl) Pyridin-2 (1H)-One. Asian J. Research Chem. 2(4):Oct.-Dec. 2009 page 434-436.


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