ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): R. Xavier Arulappa, M.Sundarapandian, Rithesh Singh, S.Venkataraman

Email(s): xavilatha@yahoo.co.in

DOI: Not Available

Address: R. Xavier Arulappa*1, M.Sundarapandian2, Rithesh Singh1, and S.Venkataraman1
Department of Pharmaceutical Chemistry1, Department of Pharmaceutical Analysis2 K.M.College of Pharmacy, Uthangudi, Madurai –107 (India)
*Corresponding Author

Published In:   Volume - 2,      Issue - 4,     Year - 2009


ABSTRACT:
A simple, precise and accurate spectrophotometric method has been developed for the determination of Quetiapine fumarate in bulk drug and pharmaceutical dosage form. Standard stock solution was prepared in distilled water and further dilution was carried out with distilled water. The ?max of Quetiapine fumarate was found to be 290nm. The A(1%,1cm) value of Quetiapine fumarate was found to be 186.22 ± 3.11. Calibration graph was linear over the range of 5-25 µg/ml. The correlation coefficient (r) was found to be 0.9997. The limit of detection (LOD) and limit of Quantification (LOQ) was found to be 0.41 µg/ml and 1.25 µg/ml respectively of Quetiapine fumarate. The result of estimation in marketed tablet formulations were found to be 100.64 ± 0.18 and 101.32 ±0.35. The proposed method was applied successfully for the determination of Quetiapine fumarate in tablets with average recovery of 102 ± 1.14 and 98.8 ± 1.10. The method was then validated statistically as per ICH guidelines, which yielded good results concerning range, linearity, precision and accuracy.


Cite this article:
R. Xavier Arulappa, M.Sundarapandian, Rithesh Singh, S.Venkataraman. Spectrophotometric Method for Estimation of Quetiapine Fumarate in Bulk and Dosage Form. Asian J. Research Chem. 2(4):Oct.-Dec. 2009 page 452-453.


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