ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): K Ananda kumar, G Kumaraswamy, T Ayyappan, ASK Sankar, D Nagavalli

Email(s): anandkarunakaran@gmail.com

DOI: Not Available

Address: K Anandakumar*, G Kumaraswamy, T Ayyappan, ASK Sankar and D Nagavalli
Adhiparasakthi College of Pharmacy, Melmaruvathur - 603 319, Tamil Nadu, India
*Corresponding Author

Published In:   Volume - 3,      Issue - 1,     Year - 2010


ABSTRACT:
A simple, selective, linear, precise and accurate RP-HPLC method was developed and validated for rapid assay of Eszopiclone (ESZ) in bulk and in tablet dosage form. Isocratic elution at a flow rate of 1ml/ min was employed on a Phenomenax Luna C18 column (150 ? 4.6 mm; 5?) at ambient temperature. The mobile phase consisted of Acetonitrile: phosphate buffer adjusted to pH 2.5 (25:75% v/v). The UV detection wavelength was 304 nm and 20 ?l of sample was injected. The retention time for ESZ was 3.92 min. The method obeys Beer's law in the concentration range of 4-24 ?g/ ml. The amount of Eszopiclone Present in the formulation was found to be 99.60 ? 1.5389. The % recovery was in the range between 99.25% and 99.86%. The percentage RSD for precision and accuracy of the method was found to be less than 2 %. The method was validated as per the standard analytical procedures and statistical parameters. The method was successfully applied for routine analysis of ESZ in bulk and in formulation.


Cite this article:
K Ananda kumar, G Kumaraswamy, T Ayyappan, ASK Sankar, D Nagavalli. Validated RP-HPLC Method for the Estimation of Eszopiclone in Bulk and Tablet Dosage Form. Asian J. Research Chem. 3(1): Jan.-Mar. 2010; Page 63-66.


Recomonded Articles:

Author(s): Vatchavai Bhaskara Raju, Bonthu Mohan Gandhi, Kamatham Srinivas Sumanth, Kolli Srinivas, Tupakula N Venkata Lakshmi Neeraja

DOI: 10.5958/0974-4150.2017.00030.X         Access: Open Access Read More

Author(s): SS Chitlange, Kiran Bagri, DM Sakarkar

DOI:         Access: Open Access Read More

Author(s): B. Balaswami, P. Venkata Ramana, B. Subba Rao, P. Sanjeeva

DOI: 10.5958/0974-4150.2018.00023.8         Access: Open Access Read More

Author(s): Ismail, R Rajavel, M Ganesh, M Jagadeeswaran, K Srinivasan, J Valarmathi, T Sivakumar

DOI:         Access: Open Access Read More

Author(s): Sachin R Shinde , Suvarna I Bhoir, Namdev S Pawar, Suman B Yadav, Ajay S Ghumatkar, Ashok M Bhagwat

DOI:         Access: Open Access Read More

Author(s): Prasanna Reddy Battu, MS Reddy

DOI:         Access: Open Access Read More

Author(s): Babu Ganesan, Perumal Perumal, Vijaya Baskaran Manickam, Surya Rao Srikakolapu, Srujana Divya Gotteti, Latha Sundaresan Thirumurthy

DOI:         Access: Open Access Read More

Author(s): Kathiravan S., Anbarasi B., Mathankumar S.

DOI:         Access: Open Access Read More

Author(s): Nilesh Jain, Ruchi Jain, Hemant Swami, Deepak Kumar Jain

DOI:         Access: Open Access Read More

Author(s): Ravi Pratap Pulla, B.S. Sastry, Y. Rajendra Prasad, N. Appala Raju

DOI:         Access: Open Access Read More

Author(s): Mayanka Singh, Manoj S. Charde, Rita M. Charde

DOI:         Access: Open Access Read More

Author(s): R.S. Sakhare, A.B. Roge, R.L. Bakal, A.D. Dewani, M.D. Kshirsagar, A.V. Chandewar

DOI:         Access: Open Access Read More

Author(s): Rajesh Balkrishna Tawade, Abha Sham Dhomane

DOI:         Access: Open Access Read More

Author(s): Deepa R. Patel, Laxmanbhai J. Patel, Madhabhai M. Patel

DOI:         Access: Open Access Read More

Author(s): Prabhu S, Vijay Amirtharaj R, Senthilkumar N

DOI:         Access: Open Access Read More

Author(s): Bhavna Patel, Zarna Dedania, Ronak Dedania, Chetan Ramolia, G Vidya Sagar, Mehta RS

DOI:         Access: Open Access Read More

Asian Journal of Research in Chemistry (AJRC) is an international, peer-reviewed journal devoted to pure and applied chemistry..... Read more >>>

RNI: Not Available                     
DOI: 10.5958/0974-4150 

Popular Articles


Recent Articles




Tags