Asian Journal of Research in Chemistry

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0974-4150 (Online)
0974-4169 (Print)


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Synthesis and Antimicrobial Evaluation of Benzimidazole Analogs

Author(s): YS Rane, RR Varma, LS Patil, SV Athlekar, AS Chowdhary, AS Bobade

Email(s): yora_03@yahoo.com , rajeevvarma84@gmail.com

DOI: Not Available

Address: YS Rane, RR Varma, LS Patil, SV Athlekar, AS Chowdhary and AS Bobade*
Department of Chemotherapy, Haffkine Institute for Training, Research and Testing, Parel Mumbai -12
*Corresponding Author

Published In:   Volume - 3,      Issue - 2,     Year - 2010

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ABSTRACT:
A series of benzimidazole phenylthiocarbamoyl derivatives were synthesized by condensing substituted 2-mercaptobenzimidazole with substituted benzoyl chlorides. These benzimidazole derivatives were evaluated for their antibacterial activity against Gram Positive bacteria Staphylococcus aureus (ATCC 3750) and Gram Negative bacteria Salmonella typhi (NCTC 786), as well as antifungal activity against a fungal strain Candida albicans (ATCC 10231). It was observed that the 5-naphthoxy-6-chloro benzimidazole derivatives having dichloro substitutions on the phenylthiocarbamoyl part of the molecule showed better activity than the rest.


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Cite this article:
YS Rane, RR Varma, LS Patil, SV Athlekar, AS Chowdhary, AS Bobade. Synthesis and Antimicrobial Evaluation of Benzimidazole Analogs. Asian J. Research Chem. 3(2): April- June 2010; Page 342-345.


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Asian Journal of Research in Chemistry (AJRC) (ISSN: print-0974-4169, Online-0974-4150) is an international, peer-reviewed journal devoted to pure and applied chemistry. AJRC publishes Original Research Articles, Short Communications, Review Articles in all aspects of chemistry. Topics covered including the traditional areas of analytical, inorganic, organic, biochemistry, forensic, physical-theoretical chemistry as well as newer interdisciplinary areas such as agriculture, materials science, computational, medicine, spectroscopy, polymers, supramolecular, surface, chemical physics, biological, medicinal/ drugs, environmental and pharmaceutical chemistry.
The journal is published quarterly every year in last week of March, June, September and December. From January 2011, is monthly and shall be published every year in last week of Month.    
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