T Venkatachalam, V Kishor Kumar, P Kalai Selvi, R Srinivasan, R Mariammal, KG Lalitha
T Venkatachalam1*, V Kishor Kumar1, P Kalai Selvi1, R Srinivasan1, R Mariammal2, KG Lalitha3
1JKKMMRF College of Pharmacy B. Komarapalayam
2ROVER College of Pharmacy .Perambalur
3ULTRA College of Pharmacy. Madurai
Volume - 3,
Issue - 2,
Year - 2010
Simple, sensitive, and specific spectrophotometric methods were developed and validated for quantitation of Metoprolol succinate and Hydrochlorthiazide in tablet dosage form. A new analytical method was developed based on the simultaneous estimation of drugs in a binary mixture without previous separation. In simultaneous equation method, Metoprolol succinate and Hydrochlorthiazide were determined by using their absorptivity values at wavelength maxima, viz., 222 nm and 272 nm. The standard deviation value for the different validation parameters was found to be between 0.094 and 1.01 for simultaneous equation method. This method is simple, accurate, rapid, and they require no preliminary separation and can therefore be used for routine analysis of both drugs in quality control laboratories.
Cite this article:
T Venkatachalam, V Kishor Kumar, P Kalai Selvi, R Srinivasan, R Mariammal, KG Lalitha. New Spectrophotometric Method Applied to the Simultaneous Determination of Metoprolol Succinate and Hydrochlorthiazide. Asian J. Research Chem. 3(2): April- June 2010; Page 464-467.