ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): Ravinder Burugu, G. Venkateshwarlu

Email(s): ravinder.burugu@gmail.com

DOI: Not Available

Address: Ravinder Burugu1* and G. Venkateshwarlu2
1Bioplus Life Sciences Pvt. Ltd.,Whitefield Road, Bangalore-560048
2Department of chemistry, NIZAM College, Osmania University, Hyderabad
*Corresponding Author

Published In:   Volume - 3,      Issue - 3,     Year - 2010


ABSTRACT:
A simple, specific, accurate and precise high performance liquid chromatographic method was developed for the determination of Amlodipine and Atorvastatin in Amlodipine besylate and Atorvastatin tablet dosage forms. A Hypersil BDS C18 5µm (250x4.6mm I.D) with column temperature 30°C in isocratic mode, with mobile phase containing Acetonitrile: 10mM Ammonium acetate buffer pH 4.0 (50:50) was used. The flow rate was 1.0mL/min and effluent was monitored at 238nm.The retention time of Amlodipine was 2.5min and for Atorvastatin was 4.7min.The linearity for Amlodipine and Atorvastatin was in the range 0.02mg/mL to 0.12mg/mL.The proposed method is accurate, precise, specific and rapid estimation of Amlodipine and Atorvastatin in Amlodipine besilate and Atorvastatin tablets.


Cite this article:
Ravinder Burugu, G. Venkateshwarlu. RP-HPLC Determination of Amlodipine Besylate and Atorvastatin from Tablets Dosage forms. Asian J. Research Chem. 3(3): July- Sept. 2010; Page 763-766.


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