ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): Parag R. Patel, Vandana B. Patel, Mayank Bapna

Email(s): vbpatel04@yahoo.com

DOI: Not Available

Address: Parag R. Patel1, Vandana B. Patel2* and Mayank Bapna2
1Pharmaceutical Quality Assurance Laboratory, Pharmacy Department, Faculty of Technology and Engineering, The Maharaja Sayajirao University of Baroda, Vadodara 390 001, Gujarat (India)
2 Baroda College of Pharmacy, P.O. Limda, Ta. Waghodia, Dist. Vadodara, Pin 391 760 Gujarat (India)
*Corresponding Author

Published In:   Volume - 3,      Issue - 4,     Year - 2010


ABSTRACT:
Rapid, precise, accurate and specific ratiospectra derivative spectrophotometry and high-performance liquid chromatography procedures were described for the simultaneous determination of levofloxacin and ornidazole in their combined dosage forms. For the first method of ratiospectra derivative spectrophotometry the signals were measured at 302 nm for ornidazole and 292.8 nm for levofloxacin as a mixture. The second method is based on high performance liquid chromatography (HPLC) on Princeton RP-C18 column (5µ, 150x4.6mm) using 0.1% v/v triethylamine-acetonitrile (80:20, v/v) (pH 6.0). Detection was carried out using a UV detector at 295 nm. The retention time for levofloxacin and ornidazole were found to be 2.8 min and 4.4 min respectively. Both the methods showed good linearity in the range of 1 to 20µg/mL and 5 to 5000ng/ml for ratiospectra derivative spectroscopy and HPLC respectively. Pharmaceutical formulations containing both drugs were successfully assayed using the developed methods.


Cite this article:
Parag R. Patel, Vandana B. Patel, Mayank Bapna. Simultaneous Determination of Levofloxacin and Ornidazole by Ratiospectra Derivative Spectrophotometry and High Performance Liquid Chromatography. Asian J. Research Chem. 3(4): Oct. - Dec. 2010; Page 922-927.


Recomonded Articles:

Author(s): Vatchavai Bhaskara Raju, Bonthu Mohan Gandhi, Kamatham Srinivas Sumanth, Kolli Srinivas, Tupakula N Venkata Lakshmi Neeraja

DOI: 10.5958/0974-4150.2017.00030.X         Access: Open Access Read More

Author(s): Tauseef Shaikh, Atar Mujum , Khan Wasimuzzama, Rukhsana A Rub

DOI:         Access: Open Access Read More

Author(s): Y. Padmavathi, Akari Anjali, Nayaka Raghavendra Babu, P Ravi Kumar

DOI: 10.5958/0974-4150.2017.00064.5         Access: Open Access Read More

Author(s): Alka Verma, Bhupesh Verma, Sunil Kumar Prajapati, Kishu Tripathi

DOI:         Access: Open Access Read More

Author(s): Banerjee S, Bonde CG, Merukar SS, Patil YR

DOI:         Access: Open Access Read More

Author(s): SS Chitlange, Kiran Bagri, DM Sakarkar

DOI:         Access: Open Access Read More

Author(s): B. Balaswami, P. Venkata Ramana, B. Subba Rao, P. Sanjeeva

DOI: 10.5958/0974-4150.2018.00023.8         Access: Open Access Read More

Author(s): Manorama B. Motegaonkar, S. D. Salunke

DOI: 10.5958/0974-4150.2017.00025.6         Access: Open Access Read More

Author(s): PA Jadhav, CS Raut, JP Bidada, BB Buwa, PN Dhabale, SC Dhawale

DOI:         Access: Open Access Read More

Author(s): K. Kishore Kumar, R.S.K. Sharma, P. Chanti Babu, M. Sreenivasa Rao, K. Durga Prasadu, D. Ravi Kumar

DOI: 10.5958/0974-4150.2017.00067.0         Access: Open Access Read More

Author(s): S. Ganapathy, G.V.H. Raju, D.G. Sankar, Pettla Y. Naidu

DOI:         Access: Open Access Read More

Asian Journal of Research in Chemistry (AJRC) is an international, peer-reviewed journal devoted to pure and applied chemistry..... Read more >>>

RNI: Not Available                     
DOI: 10.5958/0974-4150 

Popular Articles


Recent Articles




Tags