A simple, sensitive and reproducible UV-Visible spectrophotometric methods (Method A to Method C) are developed for the determination of Tadalafil (TADL) in pure and dosage forms. Method A is based on the formation of colored species on treatment of Tadalafil (TADL) with Folin- Ciocalteu reagent in presence of 4% NaOH Solution. Method B is based on the formation of colored species on treatment of Tadalafil (TADL) with Sodium nitroprusside and Hydroxyl amine .Method C represents UV Spectrophotometric determination of Tadalafil (TADL) and its dosage forms in pH 2.9Buffer : Acetonitrile (40:60v/v) at 285nm.
Cite this article:
G.V.H. Raju, S. Ganapathy, D.G. Sankar, P.Y. Naidu. New UV-Visible Spectrophotometric Methods for the Determination of Tadalafil in Bulk and Pharmaceutical Formulation. Asian J. Research Chem. 3(4): Oct. - Dec. 2010; Page 958-960.