ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): Radhika C., Venkatesham Akena, Venkateshwar Rao J., Sarangapani M.

Email(s): cradhika8@gmail.com

DOI: Not Available

Address: Radhika C.1, Venkatesham Akena2, Venkateshwar Rao J.1, Sarangapani M.2* 1Talla Padmavathi College of Pharmacy, Orus, Warangal-506009, A.P, India 2University College of Pharmaceutical Sciences, Kakatiya University, Warangal-506009, A.P, India
*Corresponding Author

Published In:   Volume - 3,      Issue - 4,     Year - 2010


ABSTRACT:
Some new (Napthalen-1-yloxyl/ 2-yloxy) - acetic acid (2-oxo-1, 2-dihydro-indole-3-ylidene)-hydrazides (4 and 5) have been synthesized by condensing naphthyl-1-oxy/2-oxy acetic acid hydrazides with different isatins. Their chemical structures have been confirmed by IR, NMR, and Mass spectroscopy and by elemental analysis. Investigation of cytotoxic activity was done by MTT assay method using HeLa and MCF cell lines. The compounds with 6-Bromo substitution (4e, 5e) have shown the prominent cytotoxic activity among the synthesized compounds.


Cite this article:
Radhika C., Venkatesham Akena, Venkateshwar Rao J., Sarangapani M.. Synthesis and Cytotoxic Activity of New Indole Derivatives. Asian J. Research Chem. 3(4): Oct. - Dec. 2010; Page 965-968.


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Asian Journal of Research in Chemistry (AJRC) is an international, peer-reviewed journal devoted to pure and applied chemistry..... Read more >>>

RNI: Not Available                     
DOI: 10.5958/0974-4150 

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