Radhika C., Venkatesham Akena, Venkateshwar Rao J., Sarangapani M.
Radhika C.1, Venkatesham Akena2, Venkateshwar Rao J.1, Sarangapani M.2*
1Talla Padmavathi College of Pharmacy, Orus, Warangal-506009, A.P, India
2University College of Pharmaceutical Sciences, Kakatiya University, Warangal-506009, A.P, India
Volume - 3,
Issue - 4,
Year - 2010
Some new (Napthalen-1-yloxyl/ 2-yloxy) - acetic acid (2-oxo-1, 2-dihydro-indole-3-ylidene)-hydrazides (4 and 5) have been synthesized by condensing naphthyl-1-oxy/2-oxy acetic acid hydrazides with different isatins. Their chemical structures have been confirmed by IR, NMR, and Mass spectroscopy and by elemental analysis. Investigation of cytotoxic activity was done by MTT assay method using HeLa and MCF cell lines. The compounds with 6-Bromo substitution (4e, 5e) have shown the prominent cytotoxic activity among the synthesized compounds.
Cite this article:
Radhika C., Venkatesham Akena, Venkateshwar Rao J., Sarangapani M.. Synthesis and Cytotoxic Activity of New Indole Derivatives. Asian J. Research Chem. 3(4): Oct. - Dec. 2010; Page 965-968.