Author(s):
Meet Agrawal, Drashti Dave
Email(s):
meetagrawal1234567@gmail.com , drashtidave.2702@gmail.com
DOI:
10.52711/0974-4150.2025.00052 
Address:
Meet Agrawal1, Drashti Dave2
1UG Scholar, Sigma Institute of Pharmacy, Bakrol, Ajwa Road, Vadodara, Gujrat, India.
2Assistant Professor, Department of Pharmaceutics, Sigma Institute of Pharmacy, Sigma University, Bakrol, Ajwa Road, Vadodara, Gujrat, India.
*Corresponding Author
Published In:
Volume - 18,
Issue - 5,
Year - 2025
ABSTRACT:
Quantum dots (QDs) are semiconductor nanocrystals that are quickly emerging as potentially useful biomedical technologies as a result of their unique optical and physicochemical properties. QDs may be an ideal route for drug delivery due to their multitude of advantageous and unprecedented properties, such as Tenable emission spectra, high brightness, photostable behaviour, and thermostatic potential (imaging and therapy through the same vehicle). Also, QDs may provide the benefit of being nanoscale, which is an advantage for cellular uptake and targeted delivery within the cell at a particular area. QDs have the ability to be readily surface modified and conjugated to specific ligands, antibodies, and/or therapeutic agents. When put together with a multifunctional drug delivery vehicle, QDs may provide ever more localized effects and less systemic toxicities overall. Advancements in QD development, including synthesis, surface modification and biocompatibility may move forward QDs in personalized medicine to enable real time drug distribution, release and therapeutic response testing. While there are certainly concerns with toxicity and biodegradability for QDs and QD systems, advancements in biocompatibility and carbon-based QDs may alleviate some of these issues. This review will provide an overview of the current developments, potential applications and future possibilities for QDs drug delivery systems and their potential to serve as a disruptive technology in personalized and precision medicine.
Cite this article:
Meet Agrawal, Drashti Dave. Quantum Dots in Drug Delivery: A New Era of Precision Medicine. Asian Journal of Research in Chemistry. 2025; 18(5):337-4. doi: 10.52711/0974-4150.2025.00052
Cite(Electronic):
Meet Agrawal, Drashti Dave. Quantum Dots in Drug Delivery: A New Era of Precision Medicine. Asian Journal of Research in Chemistry. 2025; 18(5):337-4. doi: 10.52711/0974-4150.2025.00052 Available on: https://ajrconline.org/AbstractView.aspx?PID=2025-18-5-7
9. REFERENCES:
1. Chan WCW, Maxwell DJ, Gao XH, Bailey RE, Han MY, Nie SM. Luminescent quantum dots for multiplexed biological detection and imaging. Curr Opin Biotechnol. 2002; 13(1): 40–6.
2. Efros AL, Efros AL. Interband absorption of light in a semiconductor sphere. Sov Phys Semicond, 1982; 16: 772–5.
3. Boroditsky E, Shur MS, editors. Quantum Dots. Vol. 25. New Jersey: World Scientific; 2002.
4. Bruchez M, Morone M, Gin P, Weiss S, Alivisatos AP. Semiconductor nanocrystals as fluorescent biological labels. Science. 1998; 281(5385): 2013–6.
5. Bang J, Yang H, Holloway PH. Enhanced and stable green emission of ZnO nanoparticles by surface segregation of Mg. Nanotechnology. 2006; 17(4): 973–8.
6. Kocur E, Bucking W, Giernoth R, Nann T. Evaluation of defect states in semiconductor nanocrystals by cyclic voltammetry. J Phys Chem B. 2005; 109(43): 20355–60.
7. Bera D, Qian L, Tseng TK, Holloway PH. Quantum dots and their multimodal applications: an overview of the literature. Materials. 2010; 3(4): 2260–345.
8. Pillar-Little TJ, Ramanayake N, Nease L, Heidary DK, Glazer EC, Kim DY. Enhanced photodynamic efficacy of carbon quantum dots via both type I and type II mechanisms: a comprehensive comparative study of top-down-synthesized and bottom-up-synthesized carbon quantum dots. Nanoscale Adv. 2018; 1(3): 616–23.
9. Drummen GP. Quantum dots – from synthesis to application in biomedicine and the life sciences. Int J Mol Sci. 2010; 11(1): 154–63.
10. Wang C, Jiang Z, Wei L, Chen Y, Wei L, Jiao J, et al. Photosensitized TiO2 nanorods with CDs quantum dots for photovoltaic applications – a wet-chemical route. J Mater Chem. 2012; 22(1): 440–7.
11. Bang J, Yang H, Holloway PH. Enhanced and stable green emission of ZnO nanoparticles by surface segregation of Mg. Nanotechnology. 2006; 17(4): 973–8.
12. Yang H, Holloway PH, Cunningham G, Schanze KS. CdS:Mn nanocrystals passivated by ZnS: synthesis and luminescent properties. J Chem Phys. 2004; 121(21): 10233–40.
13. Zhu JJ, Koltypin Y, Gedanken A. General nonchemical method for the preparation of nanophase selenides: synthesis of ZnS nanoparticles. Chem Mater. 2000; 12(1): 73–8.
14. Qu LH, Peng XG. Control of photoluminescence properties of CdS nanocrystals in growth. J Am Chem Soc. 2002; 124(9): 2049–55.
15. Lee H, Holloway PH, Yang H. Synthesis and characterization of colloidal ternary Zn–CdS semiconductor nanorods. J Chem Phys. 2006; 125(23): 2343181.
16. Xin SH, Wang PD, Yin A, Kim C, Dobrowolska M, Merz JL, et al. Formation of self-assembling CdS quantum dots on ZnS by molecular beam epitaxy. Appl Phys Lett. 1996; 69(26): 3884–6.
17. Leonard D, Krishnamurthy M, Reaves CM, Debars SP, Petroff PM. Direct formation of quantum-sized dots from uniform coherent islands of InGaAs on GaAs surfaces. Appl Phys Lett. 1993; 63(23): 3203–5.
18. Bailey RE, Smith AM, Nie S. Quantum dots in biology and medicine. Phys E. 2004; 25(1): 1–12.
19. Michalet X, Pinaud FF, Bentolila LA, Tsay JM, Doose S, Li JJ, et al. Quantum dots for live cells, in vivo imaging, and diagnostics. Science. 2005; 307(5709): 538–44.
20. Gidde ND, Raut ID, Nitalikar MM, Mohite SK, Magdum CS, Pharmacosomes as drug delivery system: an overview. Asian J Pharm Res. 2021; 11(2): 122–7.
21. Jire DS, Gosavi NS, Badhe RB, Jagdale DH. Mouth dissolving tablet: a novel drug delivery system. Asian J Pharm Res. 2021; 11(3): 180–6.
22. Ahmad W, Khan T, Basit I, Imran J. A comprehensive review on targeted drug delivery system. Asian J Pharm Res. 2022; 12(4): 335–40.
23. Shinde S, Patil A, Gaikwad R. Graphene quantum dots: a pharmaceutical review. Asian J Pharm Res. 2022; 12(4): 341–8.
24. Shinde S, Patil A, Gaikwad R. Graphene quantum dots: a pharmaceutical review. Asian J Pharm Res. 2022; 12(4): 341–8.
25. Sarella PNK, Vegi S, Vendi VK, Vipparthi AK, Valluri S. Exploring aquasomes: a promising frontier in nanotechnology-based drug delivery. Asian J Pharm Res. 2024; 14(2): 153–61.
26. Singh I. A review on in-vivo imaging of cancer cells by bioconjugated quantum dots. Asian J Pharm Res. 2018; 8(4): 243–8.
27. Hande AV, Maner SS, Jadhav PP, Kamble DD. Quantum dots and their medical importance. Asian J Res Pharm Sci. 2024; 14(4): 381–3.
28. Saravanan V, Tippavajhala VK. Quantum dots: targeted and traceable drug delivery system. Res J Pharm Technol. 2022; 15(12): 5895–902.
29. Bhave D, Deshpande S, Dabholkar U. Surfactants as quantum dots used in bio-imaging. Res J Sci Technol. 2018; 10(3): 188–96.
30. Patel J, Mota P, Salvi A, Goswami P, Kerawala MAK. Infrared organic photovoltaic: a review. Res J Eng Technol. 2017; 8(2): 159–64.
31. Saudagar RB, Mandlik KT. A review on gold nanoparticles. Asian J Pharm Res. 2016; 6(1): 45–8.