Author(s):
Abhimanyu Pawar, Kishor Naktode, Arvind Mungole, Dalesh Parshuramkar
Email(s):
abhaypawar1988@gmail.com
DOI:
10.52711/0974-4150.2025.00047 
Address:
Abhimanyu Pawar1*, Kishor Naktode1, Arvind Mungole2, Dalesh Parshuramkar3
1Department of Chemistry, Nevjabai Hitkarini College, Bramhapuri, Maharashtra 441206, India.
2Department of Botany, Nevjabai Hitkarini College, Bramhapuri, Maharashtra 441206, India.
3Department of Physics, Nevjabai Hitkarini College, Bramhapuri, Maharashtra 441206, India.
*Corresponding Author
Published In:
Volume - 18,
Issue - 5,
Year - 2025
ABSTRACT:
We developed a sustainable and efficient protocol for synthesizing isoxazol-5(4H)-one derivatives using green synthesized silver nanoparticles as a green nonocatalyst. The one-pot, three-component reaction of aromatic aldehydes, ethyl acetoacetate, and hydroxylamine hydrochloride proceeded smoothly in aqueous phase at room temperature, affording the target compounds in high to excellent yields with short reaction times. The plant-derived silver nanoparticles demonstrated exceptional catalytic activity while offering advantages such as low toxicity, cost-effectiveness, and easy handling. Notably, electron-donating substituents on the aromatic aldehydes enhanced reactivity, whereas steric and electronic factors influenced reaction efficiency. This method aligns with green chemistry principles by eliminating organic solvents, minimizing energy consumption, and utilizing a biodegradable catalyst. The protocol provides a practical, eco-friendly, and scalable approach to heterocyclic synthesis, making it a valuable addition to sustainable organic transformations.
Cite this article:
Abhimanyu Pawar, Kishor Naktode, Arvind Mungole, Dalesh Parshuramkar. Biosynthesized Silver Nanoparticles Catalyzed Aqueous-Phase Synthesis of Isoxazol-5(4H)-One Derivatives. Asian Journal of Research in Chemistry. 2025; 18(5):311-8. doi: 10.52711/0974-4150.2025.00047
Cite(Electronic):
Abhimanyu Pawar, Kishor Naktode, Arvind Mungole, Dalesh Parshuramkar. Biosynthesized Silver Nanoparticles Catalyzed Aqueous-Phase Synthesis of Isoxazol-5(4H)-One Derivatives. Asian Journal of Research in Chemistry. 2025; 18(5):311-8. doi: 10.52711/0974-4150.2025.00047 Available on: https://ajrconline.org/AbstractView.aspx?PID=2025-18-5-2
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