ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): Vandana B. Patel, Rajnikanta Sahu, Bhumika M. Patel

Email(s): vbpatel04@yahoo.com

DOI: Not Available

Address: Vandana B. Patel1*, Rajnikanta Sahu2 and Bhumika M. Patel1
1Baroda College of Pharmacy, Limda, Vadodara, Gujarat, India
2Department of Pharmacy, The Maharaja Sayajirao University of Baroda, Gujarat, India
*Corresponding Author

Published In:   Volume - 4,      Issue - 1,     Year - 2011


ABSTRACT:
Two simple, accurate and precise methods viz. first derivative zero crossing spectrophotometry (method 1) and derivative ratio spectra zero crossing method (method 2) have been developed for simultaneous determination of amlodipine besylate and atorvastatine calcium in pure and commercial formulation without any prior separation or purification. The linearity range was found to be 5- 40 µg ml-1 for both the drugs. The value of limit of detection and limit of quantification was 0.397 µg ml-1 and 1.323 µg ml-1 for amlodipine and 0.220µg ml-1 and 0.735 µg ml-1 for atorvastatine respectively for method 1 and 0.600 µg ml-1 and 0.262 µg ml-1 for amlodipine and 0.262µg ml-1 and 0.874 µg ml-1 for atorvastatine respectively for method 2. The method was satisfactorily validated in terms of accuracy and precision. The results of the study showed that the proposed spectrophotometric methods are useful for the routine determination of amlodipine and atorvastatin in its combined pharmaceutical tablet dosage form.


Cite this article:
Vandana B. Patel, Rajnikanta Sahu, Bhumika M. Patel. Simultaneous Determination of Amlodipine Besylate and Atorvastatin Calcium in Pharmaceutical Tablet Formulation by Derivative Spectrophotometric Method. Asian J. Research Chem. 4(1): January 2011; Page 128-131.


Recomonded Articles:

Author(s): Vatchavai Bhaskara Raju, Bonthu Mohan Gandhi, Kamatham Srinivas Sumanth, Kolli Srinivas, Tupakula N Venkata Lakshmi Neeraja

DOI: 10.5958/0974-4150.2017.00030.X         Access: Open Access Read More

Author(s): Y. Padmavathi, Akari Anjali, Nayaka Raghavendra Babu, P Ravi Kumar

DOI: 10.5958/0974-4150.2017.00064.5         Access: Open Access Read More

Author(s): Alka Verma, Bhupesh Verma, Sunil Kumar Prajapati, Kishu Tripathi

DOI:         Access: Open Access Read More

Author(s): SS Chitlange, Kiran Bagri, DM Sakarkar

DOI:         Access: Open Access Read More

Author(s): Banerjee S, Bonde CG, Merukar SS, Patil YR

DOI:         Access: Open Access Read More

Author(s): Manorama B. Motegaonkar, S. D. Salunke

DOI: 10.5958/0974-4150.2017.00025.6         Access: Open Access Read More

Author(s): PA Jadhav, CS Raut, JP Bidada, BB Buwa, PN Dhabale, SC Dhawale

DOI:         Access: Open Access Read More

Author(s): R.K. Nanda, S.E. Potawale, V.V. Bhagwat, S.C.Hamane, R. S. Deshmukh

DOI:         Access: Open Access Read More

Author(s): VB Kshirsagar, UA Deokate, VB Bharkad, SS Khadabadi

DOI:         Access: Open Access Read More

Author(s): S. Ganapathy, G.V.H. Raju, D.G. Sankar, Pettla Y. Naidu

DOI:         Access: Open Access Read More

Asian Journal of Research in Chemistry (AJRC) is an international, peer-reviewed journal devoted to pure and applied chemistry..... Read more >>>

RNI: Not Available                     
DOI: 10.5958/0974-4150 

Popular Articles


Recent Articles




Tags