ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): Shivaji Bhattacharjee, J. Saravanan, S. Mohan

Email(s): bhattacharjee.shivaji@gmail.com

DOI: Not Available

Address: Shivaji Bhattacharjee*, J. Saravanan and S. Mohan
Department of Pharmaceutical Chemistry, PES College of Pharmacy, Bangalore-50, Karnataka, India.
*Corresponding Author

Published In:   Volume - 4,      Issue - 10,     Year - 2011


ABSTRACT:
2-amino-4-(4-chlorophenyl)thiophene-3carboxamide was synthesized using versatile Gewald reaction conditions started with the preparation of acetamide, which was carried out by cold condensation of aniline and ethylcynoacetate, which was then reacted with p-chloro acetophenone, sulphur, diethyl amine to give 2-amino-4-(4-chlorophenyl)thiophene-3carboxamide. Later the compound was treated with twelve different substituted aryl aldehydes to yield twelve new Schiff bases (SBJ-Ia-l). The compounds were characterized by IR, 1H NMR and Mass spectral data and screened for CNS depressant activity.


Cite this article:
Shivaji Bhattacharjee, J. Saravanan, S. Mohan. Synthesis, Characterization and CNS Depressant Activity of Some Schiff Bases of 2-Amino-4-(4-Chlorophenyl)Thiophene-3carboxamide. Asian J. Research Chem. 4(10): Oct., 2011; Page 1562-1565.


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