ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): S. Singh, P. K. Sharma, R. Dudhe, N. Kumar

Email(s): Sudha.singh758@gmail.com

DOI: Not Available

Address: S. Singh*, P. K. Sharma, R. Dudhe and N. Kumar
Department of Pharmaceutical Technology, Meerut Institute of Engineering and Technology, Meerut NH-58, Bypass Road, Baghpat Crossing, Meerut- 250005, U.P., India.
*Corresponding Author

Published In:   Volume - 4,      Issue - 10,     Year - 2011


ABSTRACT:
A novel series of substituted pyrazolopyrimidine derivatives have been synthesized from substituted hydrazine derivatives and ethoxy (methylene)malanonitrile gives an intermediate (5-amino-1- substituted phenyl pyrazole-4-carbonitrile) (1) which on further react with formic acid, acetic acid/HCl and formamide gives series of (1- substituted phenyl)1H pyrazole [3,4-d] pyrimidine-4(5H)-one (2). The synthesized compounds were characterized on the basis of IR, 1H NMR and mass spectral data. Furthermore, these newly synthesized compounds were screened for their antibacterial activity against Staphylococcus aureus and Pseudomonas aeruginosa. Compounds PP-6A, PP-2B, PP-3B and PP-5C showed significant antibacterial activity.


Cite this article:
S. Singh, P. K. Sharma, R. Dudhe, N. Kumar. Synthesis of Pyrazolopyrimidine Derivatives and Their Antibacterial Activity. Asian J. Research Chem. 4(10): Oct., 2011; Page 1594-1599.


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