CH Narasimha Raju BH, N. Delhiraj, G. Devala Rao
CH Narasimha Raju BH1*, N. Delhiraj2 and G. Devala Rao3
1Research Scholar, Prist University, Vallam, Thanjavur, Tamil Nadu
2Department of Pharmaceutical Analysis, Nimra College of Pharmacy, Vjayawada, A.P
3Department of Pharmaceutical Analysis, K.V.S.R Siddhartha College of Pharmaceutical Sciences, Vijayawada, A. P.
Volume - 4,
Issue - 11,
Year - 2011
Two simple, sensitive and cost effective Spectrophotometric methods are developed for the determination of Racecadotril in bulk drug and pharmaceutical dosage forms. The methods are based on the oxidation of Racecadotril by ferric chloride in presence of Bathophenanthroline (Method A) and reduction of Folin ciocalteau reagent in the presence of sodium carbonate (Method B). The colored complex formed was measured at 603 and 742 nm for methods A and B respectively against the reagent blank prepared in the same manner. The optimum experimental parameters for the color production are selected. Beer’s law is valid within a concentration range of 20-120 µg/ml and 20-140 µg/ml for method A and B respectively. The mean percentage recoveries are 98.2 and 100.02 for method A and B respectively. The developed methods are applied for the determination of Racecadotril in bulk and its pharmaceutical formulations without any interference from excipients.
Cite this article:
CH Narasimha Raju BH, N. Delhiraj, G. Devala Rao. Spectrophotometric Methods for the Determination of Racecadotril in Bulk and Pharmaceutical Dosage Forms. Asian J. Research Chem. 4(11): Nov., 2011; Page 1739-1741.