Arvind B. Karadi, S. Appal Raju, Shobha Manjunath, Venugopal Darak
Arvind B. Karadi*, S. Appal Raju, Shobha Manjunath and Venugopal Darak
Department of Pharmaceutical Analysis, HKES’s College of Pharmacy, Sedam Road, Gulbarga, Karnataka-585105, India.
Volume - 4,
Issue - 9,
Year - 2011
Three simple, sensitive spectrophotometric methods (Method A, B and C) are developed based on the diazotization of Cefditoren Pivoxil with nitrous acid (NaNo2/ HCl) at cold temperature followed by its coupling in-situ with ß napthol (Method A) to yield deep purple coloured chromogen, diphenyl amine (Method B) to yield pink coloured chromogen, BMR (Method C) to yield purple coloured chromogen, exhibiting absorption maxima at 542, 506 and 539nm , respectively. Beer’s law was obeyed in the concentration ranges of 20-60, 10-50 and 5-30µg/ml respectively. The coloured chromogen was stable for 3-5hrs. These methods were extended to pharmaceutical formulations and there was no interference from any common excepients which are usually present in tablet dosage formulations. The results of analysis have been validated statistically and by recovery studies.
Cite this article:
Arvind B. Karadi, S. Appal Raju, Shobha Manjunath, Venugopal Darak. Spectrophotometric Determination of Cefditoren Pivoxil by Diazotization Coupling Reaction in Solid Dosage Forms. Asian J. Research Chem. 4(9): Sept, 2011; Page 1478-1481.