ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): Chittaranjan Bhanja, Satyaban Jena

Email(s): bhanjac@gmail.com

DOI: Not Available

Address: Chittaranjan Bhanja*, Satyaban Jena
Department of Chemistry, Utkal University, Bhubaneswar-751004, Odisha, India.
*Corresponding Author

Published In:   Volume - 5,      Issue - 11,     Year - 2012


ABSTRACT:
Synthesis plays a pivotalal role in any drug research and development endeavor. The ability to design the elegant and economical synthetic routes to any therapeutic target is often a major factor for making a drug a commercial winner. Retrosynthetic analysis/ Synthon disconnection approach introduced and promoted by Prof. E. J. Corey of Harvard University has emerged as a powerful means on design synthetic routes to any useful molecules of scientific or industrial interest. Exploiting the advantages of this approach, a number of synthetic schemes has been proposed for a potent anxiolytic therapeutic ‘Diazepam’ from the results of its retrosynthetic analysis. Being theoretical propositions, the actual laboratory execution requires a cross examination of so many factors such as reactions, reagents and order of events. The routes that utilise readily available starting materials, convergent, economical, safe and produce maximum yield in short reaction time, are most feasible.


Cite this article:
Chittaranjan Bhanja, Satyaban Jena. Synthetic Protocols of Best-Selling Anxiolytic Therapeutic ‘Diazepam’: A Retrosynthetic Approach. Asian J. Research Chem. 5(11): Nov., 2012; Page 1338-1345.


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