ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): Chittaranjan Bhanja, Seetaram Mohapatra

Email(s): bhanjac@gmail.com

DOI: Not Available

Address: Chittaranjan Bhanja1*, Seetaram Mohapatra2
1Department of Chemistry, Upendra Nath (Degree) College, Nalagaja, Mayurbhanj-757073, Odisha, India.
2Department of Chemistry, Ravenshaw University, Cuttack-753003, Odisha, India.
*Corresponding Author

Published In:   Volume - 5,      Issue - 2,     Year - 2012


ABSTRACT:
Synthon approach advocated by Prof. E. J. Corey of Harvard University has emerged as a powerful analytical tool of design synthetic routes for the preparation of an organic compound of any interest from readily available starting materials. This approach plays a vital role in the synthesis of medicinal compounds/drugs which is a part and parcel of modern drug discovery process. Taking the privilege of this approach, a good number of synthesis schemes has been proposed for a potent anti-diabetic agent “rosiglitazone” keeping an overview on the works published in both journals and patent literatures. The proposed synthesis planning being a theoretical investigation, the actual laboratory execution requires the cross examination of a considerable number of factors such as reactions, reagents and order of events. In actual practice, generally that route is most feasible which is cost-effective, safe, and easy to carry out and produces maximum yield in a short reaction time.


Cite this article:
Chittaranjan Bhanja, Seetaram Mohapatra. Synthon Approach in Designing Organic Synthesis: A Case Study of Rational Synthesis Design of a Potent Antidiabetic Agent “Rosiglitazone. Asian J. Research Chem. 5(2): February 2012; Page 253-258.


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