ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): Chittaranjan Bhanja, Satyaban Jena

Email(s): bhanjac@gmail.com

DOI: Not Available

Address: Chittaranjan Bhanja*, Satyaban Jena
Department of Chemistry, Utkal University, Bhubaneswar-751004, Odisha, India
*Corresponding Author

Published In:   Volume - 5,      Issue - 7,     Year - 2012


ABSTRACT:
Synthesis of pharmaceuticals/drugs for the process development, reaction condition optimization, and scale-up production is a part and parcel of modern drug discovery process. Design synthetic routes to pharmaceuticals/drugs via retrosynthetic analysis, coined by Nobel Laureate Prof. E.J. Corey of Harvard University, has emerged as a powerful analytical tool in synthetic organic/medicinal chemistry and most responsible for yielding material benefits to mankind. Keeping an overview on the works published in both journals and patent literatures a good number of synthesis schemes have been proposed in a novel way for a potent analgesic “fentanyl” from the results of its retrosynthetic analysis. In actual practice, generally that route is most feasible which is cost-effective, safe, produce maximum yield in a short reaction time under robust conditions.


Cite this article:
Chittaranjan Bhanja, Satyaban Jena. Synthesis Planning of a Potent Opioid Analgesic “Fentanyl”: A Retrosynthetic Approach. Asian J. Research Chem. 5(7): July, 2012; Page 925-931.


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