ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): Akshada N. Kakade, Shrikant B. Deshmukh, Pankaj P. Chothe, Vishal V. Khot, Shrinivas K. Mohite, Chandrakant S. Magdum

Email(s): akshadakakade@yahoo.com , dshriraj@gmail.com

DOI: Not Available

Address: Akshada N. Kakade, Shrikant B. Deshmukh, Pankaj P. Chothe, Vishal V. Khot, Dr. Shrinivas K. Mohite, Dr. Chandrakant S. Magdum
Department of Pharmaceutical Chemistry. Rajarambapu College of Pharmacy, Kasegaon, 415404, Tal: Walwa Dist: Sangli, MS.
*Corresponding Author

Published In:   Volume - 5,      Issue - 7,     Year - 2012


ABSTRACT:
Owing to the importance of partition coefficient in field of pharmaceutical education and research in the present work, We have made and attempt to determine benzene/water partition coefficient (logP) values for drugs by simple normal phase TLC technique. The partition coefficient being the relative concentration of drug in benzene/water, remains as an important physiochemical parameter which determine the absorption of drug in the body and thus influence it therapeutical response. According to literature the determination of partition coefficient is done by shake-flask method, GC, HPLC and by potentiometric method. These methods are accurate but expensive. Here there is need for simple and efficient method to determine logP value for desire drug compound or pharmaceutical research. This reasserted to come out with simple experiment technique like normal phase TLC to determine to calculate logP value. And which can be the part of under graduate laboratory practical. The differential values like Rfb/w and logRfb/logRfw were calculated and found to be closer to reported log P values (i.e from chemical abstract ACD lab), Paracetamol-0.461, Naproxen-0.769, Atenolol-0.22, Hydrochlorthiazide-0.331, Telmesertan-5.11, Pthalic acid-0.85, Sulfathiazoline-0.1, Nimesulide-0.9, Diclofenac-0.2, Benzoic acid-0.9. Considering the results we have concluded that simple and convenient TLC method was developed to determine logP values, which were matching with reported logP values of drugs bank.


Cite this article:
Akshada N. Kakade, Shrikant B. Deshmukh, Pankaj P. Chothe, Vishal V. Khot, Shrinivas K. Mohite, Chandrakant S. Magdum. A New Simple Method for Determination of Partition Coefficient by Normal Phase Thin Layer Chromatography (TLC). Asian J. Research Chem. 5(7): July, 2012; Page 922-924.


Recomonded Articles:

Author(s): Vatchavai Bhaskara Raju, Bonthu Mohan Gandhi, Kamatham Srinivas Sumanth, Kolli Srinivas, Tupakula N Venkata Lakshmi Neeraja

DOI: 10.5958/0974-4150.2017.00030.X         Access: Open Access Read More

Author(s): Tauseef Shaikh, Atar Mujum , Khan Wasimuzzama, Rukhsana A Rub

DOI:         Access: Open Access Read More

Author(s): Y. Padmavathi, Akari Anjali, Nayaka Raghavendra Babu, P Ravi Kumar

DOI: 10.5958/0974-4150.2017.00064.5         Access: Open Access Read More

Author(s): Alka Verma, Bhupesh Verma, Sunil Kumar Prajapati, Kishu Tripathi

DOI:         Access: Open Access Read More

Author(s): Banerjee S, Bonde CG, Merukar SS, Patil YR

DOI:         Access: Open Access Read More

Author(s): Manorama B. Motegaonkar, S. D. Salunke

DOI: 10.5958/0974-4150.2017.00025.6         Access: Open Access Read More

Author(s): PA Jadhav, CS Raut, JP Bidada, BB Buwa, PN Dhabale, SC Dhawale

DOI:         Access: Open Access Read More

Author(s): S. Ganapathy, G.V.H. Raju, D.G. Sankar, Pettla Y. Naidu

DOI:         Access: Open Access Read More

Author(s): J Vanitha, A Saravana Kumar, M Ganesh, VS Saravanan

DOI:         Access: Open Access Read More

Author(s): Sunil Singh, Nitin Dubey, D.K. Jain

DOI:         Access: Open Access Read More

Author(s): RB Kakde, VH Kotak, DL Kale

DOI:         Access: Open Access Read More

Asian Journal of Research in Chemistry (AJRC) is an international, peer-reviewed journal devoted to pure and applied chemistry..... Read more >>>

RNI: Not Available                     
DOI: 10.5958/0974-4150 

Popular Articles


Recent Articles




Tags