ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): Vandana P. Patil, Subhash J. Devdhe, Sachidanand S. Angadi, Suwarna H. Kale, Shital D. Phalke, Santosh D. Shelke, Rushikesh H. Patil

Email(s): vandana2609@gmail.com

DOI: Not Available

Address: Vandana P. Patil*, Subhash J. Devdhe, Sachidanand S. Angadi, Suwarna H. Kale , Shital D. Phalke, Santosh D. Shelke and Rushikesh H. Patil
Yash Institute of Pharmacy, Department of Pharmaceutical Analysis,Aurangabad-431134, India
*Corresponding Author

Published In:   Volume - 7,      Issue - 1,     Year - 2014


ABSTRACT:
A new, accurate, precise ecofriendly and economical spectrophotometric method has been developed and validated for the determination of Ketorolac Tromithamine in bulk drugs and tablet dosage forms. The proposed method is based on the reaction of ninhydrin with primary amino group present in Ketorolac Tromithamine in the presence of Ammonium Molybdate which forms Ruhemann’s purple colour by heating at 90 ± 1°C for 15 min and absorbs maximally at about 570 nm. Beer-Lambert’s law is obeyed in the concentration range of 50-250µg/ml and is described by the regression equation Y = 0.002x – 0.186 with a regression coefficient (r2) = 0.998 (n = 6). The effects of variables such as temperature, heating time, concentration of colour producing reagent and stability of colour were investigated to optimize the procedure. For the proposed method, the value of molar absorptivity and Sandell’s sensitivity are 1.03434 x 103 L/mol/cm and 0.363995µg/cm2, respectively. The LOD and LOQ are found to be 15.369 µg/ml and 46.57µg/ml, respectively. The statistically validated results indicate that the proposed method has good sensitivity, accuracy, precision and stability. Along with its cost effect, it is eco friendly and used for routine quality control of Ketorolac Tromethamine in bulk and tablet dosage forms.


Cite this article:
Vandana P. Patil, Subhash J. Devdhe, Sachidanand S. Angadi, Suwarna H. Kale , Shital D. Phalke, Santosh D. Shelke, Rushikesh H. Patil. Validated Spectrophotometric Method for the Estimation of Ketorolac Tromithamine in Bulk and Tablets Using Ninhydrin: A Modified Approach. Asian J. Research Chem 7(1): January 2014; Page 19-24.


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