Asian Journal of Research in Chemistry

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0974-4150 (Online)
0974-4169 (Print)


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Synthesis, Characterization and Anti-fungal activity of Some Novel Heterofused Thienotriazines

Author(s): H R Roopa, J. Saravanan

Email(s): roopad24@gmail.com

DOI: Not Available

Address: H R Roopa*, J. Saravanan
Department of Pharmaceutical Chemistry, PES College of Pharmacy, Bangalore-50, Karnataka, India.
*Corresponding Author

Published In:   Volume - 7,      Issue - 3,     Year - 2014

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ABSTRACT:
2-amino-3-N-(substituted carboxanilido)-4, 5-disubstituted thiophenes 1a – 1h were synthesized using versatile Gewald reaction. First step is preparation of substituted cyanoacetanilides (Comp. No JSR a and b) which was carried out by Substituted anilines and Ethyl cyano acetate which was then reacted with Methylenic ketone, ammonium acetate, glacial acetic acid, benzene, sulphur to produce 2-amino-3-N-(substituted carboxanilido)-4, 5-disubstituted thiophenes JSR 1a–1h. Later the compound was subjected to diazotization to yield eight new thieno triazines. The compounds were characterized IR, 1H NMR and mass spectral data and screened for anti-fungal activity.


Keywords:

Cite this article:
H R Roopa, J. Saravanan. Synthesis, Characterization and Anti-fungal activity of Some Novel Heterofused Thienotriazines. Asian J. Research Chem. 7(3): March 2014; Page 327-334.

Cite(Electronic):
H R Roopa, J. Saravanan. Synthesis, Characterization and Anti-fungal activity of Some Novel Heterofused Thienotriazines. Asian J. Research Chem. 7(3): March 2014; Page 327-334.   Available on: https://ajrconline.org/AbstractView.aspx?PID=2014-7-3-17


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Asian Journal of Research in Chemistry (AJRC) is an international, peer-reviewed journal devoted to pure and applied chemistry..... Read more >>>

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Asian Journal of Research in Chemistry (AJRC) (ISSN: print-0974-4169, Online-0974-4150) is an international, peer-reviewed journal devoted to pure and applied chemistry. AJRC publishes Original Research Articles, Short Communications, Review Articles in all aspects of chemistry. Topics covered including the traditional areas of analytical, inorganic, organic, biochemistry, forensic, physical-theoretical chemistry as well as newer interdisciplinary areas such as agriculture, materials science, computational, medicine, spectroscopy, polymers, supramolecular, surface, chemical physics, biological, medicinal/ drugs, environmental and pharmaceutical chemistry.
The journal is published quarterly every year in last week of March, June, September and December. From January 2011, is monthly and shall be published every year in last week of Month.    
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