ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): H R Roopa, J. Saravanan

Email(s): roopad24@gmail.com

DOI: Not Available

Address: H R Roopa*, J. Saravanan
Department of Pharmaceutical Chemistry, PES College of Pharmacy, Bangalore-50, Karnataka, India.
*Corresponding Author

Published In:   Volume - 7,      Issue - 3,     Year - 2014


ABSTRACT:
2-amino-3-N-(substituted carboxanilido)-4, 5-disubstituted thiophenes 1a – 1h were synthesized using versatile Gewald reaction. First step is preparation of substituted cyanoacetanilides (Comp. No JSR a and b) which was carried out by Substituted anilines and Ethyl cyano acetate which was then reacted with Methylenic ketone, ammonium acetate, glacial acetic acid, benzene, sulphur to produce 2-amino-3-N-(substituted carboxanilido)-4, 5-disubstituted thiophenes JSR 1a–1h. Later the compound was subjected to diazotization to yield eight new thieno triazines. The compounds were characterized IR, 1H NMR and mass spectral data and screened for anti-fungal activity.


Cite this article:
H R Roopa, J. Saravanan. Synthesis, Characterization and Anti-fungal activity of Some Novel Heterofused Thienotriazines. Asian J. Research Chem. 7(3): March 2014; Page 327-334.


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