ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): Shiva Rama Krishna Samala, Srinivasa Rao B, Kishore Gokavarapu, Sarita Gokavarapu, Sunil Gandhi

Email(s): shivarama_samala@rediffmail.com

DOI: 10.5958/0974-4150.2018.00142.6   

Address: Shiva Rama Krishna Samala1*, Srinivasa Rao B2, Kishore Gokavarapu2, Sarita Gokavarapu3, Sunil Gandhi4
1Research and Development Department, Helios Lifesciences Limited, 79 and 100, Industrial Growth Center, Malanpur, District: Bhind, MP–477117.
2Production Department, Helios Lifesciences Limited, 79 and 100, Industrial Growth Center, Malanpur, District: Bhind, MP–477117.
3QC and ADL Department, Helios Lifesciences Limited, 79 and 100, Industrial Growth Center, Malanpur, District: Bhind, MP–477117.
4Chairman, Helios Lifesciences Limited, 79 & 100, Industrial Growth Center, Malanpur,
District: Bhind, MP – 477117 *Corresponding Author

Published In:   Volume - 11,      Issue - 5,     Year - 2018


ABSTRACT:
The final stage synthesis of Sorafenib API required two key intermediates i.e., methyl-3-(4-aminophenoxy)benzoate (I) and 4-chloro-3-(trifluoromethyl)phenyl isothiocyanate(II), out of these two intermediates (I) is common and (II)is isocyanate intermediate, which is highly hazardous and creates lung problems while handling, to avoid these health, safety and environment issues instead of isocyanate we have used alternate intermediates which are different types of carbamates(III-VI), using these alternate carbamates intermediates synthesized sorafenib API with good yield and purity avoiding hazardous, synthesized these carbamates and final API were characterized by spectral data by 1H NMR, 13CNMR and HRMS.


Cite this article:
Shiva Rama Krishna Samala, Srinivasa Rao B, Kishore Gokavarapu, Sarita Gokavarapu, Sunil Gandhi. Modified reaction condition to achieve high yield and cost efficient hazardous free synthesis of Sorafenib API. Asian J. Research Chem. 2018; 11(5):806-810. doi: 10.5958/0974-4150.2018.00142.6


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