ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): Rajan V. Rele, Prathamesh P. Tiwatane

Email(s): jabourimess2@gmail.com

DOI: 10.5958/0974-4150.2020.00002.4   

Address: Rajan V. Rele*, Prathamesh P. Tiwatane
Central Research Laboratory, D.G. Ruparel College, Matunga, Mumbai 400016.
*Corresponding Author

Published In:   Volume - 13,      Issue - 1,     Year - 2020


ABSTRACT:
Simple and precise UV spectrophotometric method by area under curve [AUC] - have been developed and validated for the estimation of tenofovir disoproxil fumrate in bulk and its tablet formulation. The standard and sample solutions of tenofovir disoproxil fumrate were prepared in distilled water. Tenofovir disoproxil fumrate was estimated area under curve (AUC) method, the zero-order spectrum of tenofovir disoproxil fumrate was measured in between 255 nm to 265 nm. Beer’s law was obeyed in the concentration range of 1 to 20 µg / ml with coefficient of correlation value 0.9999. These methods were tested and validated for various parameters according to ICH guidelines. The precision expressed as relative standard deviation were of 0.1560% respectively. The proposed method was successfully applied for the determination of tenofovir disoproxil fumrate in pharmaceutical formulation. Results of the analysis were validated statistically and were found to be satisfactory. The proposed method is simple, easy to apply, low-cost and require relatively inexpensive instruments.


Cite this article:
Rajan V. Rele, Prathamesh P. Tiwatane. UV Spectrophotometric Estimation of Tenofovir Disoproxil Fumrate by area under Curve Methods in Bulk and Pharmaceutical Dosage Form. Asian J. Research Chem. 2020; 13(1): 07-11. doi: 10.5958/0974-4150.2020.00002.4


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DOI: 10.5958/0974-4150 

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